Original title: Polysacharidové gely v medicínských aplikacích
Translated title: Polysaccharide gels in medical applications
Authors: Svitačová, Denisa ; Kadlec, Martin (referee) ; Venerová, Tereza (advisor)
Document type: Bachelor's theses
Year: 2022
Language: slo
Publisher: Vysoké učení technické v Brně. Fakulta chemická
Abstract: [slo] [eng]
Táto bakalárska práca sa zaoberá hydrogélmi obsahujúcimi polysacharidy, ich charakterizáciou a reprodukovateľnosťou prípravy týchto gélov, ktorá bola popísaná v literatúre. Na základe rešerše boli vybrané vhodné polysacharidy, a to guarová guma a gellan. Následne bol vybraný článok, ktorého postup bol reprodukovaný. Na sieťovanie zmesí roztoku guarovej gumy a gellanu bol, ako gelačné činidlo, použitý chlorid vápenatý. Pri reprodukovateľnosti článku sa vyskytli problémy, ktoré neumožnili presné zopakovanie postupu prípravy hydrogélu, ktorá bola v článku popísaná. Na základe poznatkov bola vytvorená optimalizovaná rada zmesí s rôznymi prídavkami gelačného činidla. Jednotlivé pripravené materiály boli vhodne charakterizované pomocou reologických testov. Konkrétne amplitúdových testov, ktorých výsledky dokázali vznik trojrozmernej siete v ich štruktúre, a teda vznik hydrogélov. Frekvenčnými testami boli zistené ich mechanické vlastnosti. This bachelor thesis deals with the performance of hydrogels containing polysaccharides, their characterization and reproducibility of the preparation of these gels, which is described in the literature. Based on the research, suitable polysaccharides, namely guar and gellan gum, were selected. Subsequently, an article was selected, the procedure of which was reproduced. Calcium chloride was used as a crosslink agent in the mixture of guar gum and gellan solution. Problems appear in the reproducibility of the article which did not allow the exact repetition of the hydrogel preparation procedure described in the article. Based on the findings, an optimized range of mixtures with various other gelling agents was developed. The individual prepared materials were suitably characterized by rheological tests. Specifically, amplitude tests, the results of which proved the formation of a three-dimensional network in their structure, and thus the formation of hydrogels. Frequency tests were used to determine their mechanical properties.
Keywords: gellan gum; guar gum; hydrogels; polysaccharides; reproductibility; rheology

Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: http://hdl.handle.net/11012/207517

Permalink: http://www.nusl.cz/ntk/nusl-590961


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Universities and colleges > Public universities > Brno University of Technology
Academic theses (ETDs) > Bachelor's theses