Original title: Synthesis of PME derivatives on nucleobases with conformation locked via pyrrolidine ring
Authors: Rejman, Dominik ; Pohl, Radek
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year: 2011
Language: eng
Abstract: Among diverse nucleoside phosphonic acids, the acyclic phosphonate derivatives have been earlier shown to involve some exceptionally potent antiviral drugs (e.g., Cidofovir, Adefovir, and Tenofovir). This work presents the synthesis of such acyclic phosphonate nucleotides conformationally locked via pyrrolidine ring.
Keywords: conformationally locked nucleotides; locked conformation; nucleoside phosphonic acids; PME derivatives; pyrrolidine ring
Project no.: CEZ:AV0Z40550506 (CEP)
Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0198824

Permalink: http://www.nusl.cz/ntk/nusl-55827


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers