Original title:
Biological properties of the C-8 substituted analogues of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
Authors:
Janeba, Zlatko ; Holý, Antonín ; Zídek, Zdeněk Document type: Papers Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year:
2011
Language:
eng Abstract:
The 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) derivatives substituted at the C-8 position of the purine moiety did not exhibited any pronounced antiviral or antimalarial activity, but both 8-hydroxy and 8-sulfanyl derivatives of PMEA possess significant immunostimulatory activities.
Keywords:
acyclic nucleoside phosphonates; ANPs; immunostimulatory; PMEA Project no.: CEZ:AV0Z40550506 (CEP), CEZ:AV0Z50390512 (CEP), 1M0508 (CEP), GAP207/11/0108 (CEP) Funding provider: GA MŠk, GA ČR Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0198500