Název:
Phenotyping of a glutamate dehydrogenase a null mutant of \kur{Plasmodium falciparum}
Překlad názvu:
Phenotyping of a glutamate dehydrogenase a null mutant of \kur{Plasmodium falciparum}
Autoři:
PERNER, Jan Typ dokumentu: Diplomové práce
Rok:
2011
Jazyk:
cze
Abstrakt: Glutamate dehydrogenase a (GDHa) has been suggested as a potential drug target against the malaria parasite Plasmodium falciparum. GDHa knockout cell line was generated and needed a phenotypic description by means of molecular biology and biochemistry. The knockout cell line was tested for higher oxidative stress sensitivity, levels of relevant proteins and gene transcripts were quantified. Furthermore, concentrations of two key molecules enabling redox homeostasis, glutathione and NADPH, were attempted to quantify. Finally, we attempted to disrupt a gene of another glutamate dehydrogenase, gdhb, which did not result in formation of viable parasites. In conclusion, GDHa is not a suitable drug target and GDHb needs to be further elucidated.
Klíčová slova:
antioxidant defence; glutamate dehydrogenase; malaria; plasmodium falciparum Citace: PERNER, Jan. Phenotyping of a glutamate dehydrogenase a null mutant of \kur{Plasmodium falciparum}. České Budějovice, 2011. diplomová práce (Mgr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Instituce: Jihočeská univerzita v Českých Budějovicích
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Informace o dostupnosti dokumentu:
Plný text je dostupný v digitálním repozitáři JČU. Původní záznam: http://www.jcu.cz/vskp/14886