Original title: INFLUENCE OF RESPIRATORY TRACT CONDITIONS ON PARTICLE SIZE DISTRIBUTIONS GENERATED BY COMMERCIALLY AVAILABLE INHALERS
Authors: Mašková, Ludmila ; Ždímal, Vladimír ; Ondráček, Jakub
Document type: Papers
Conference/Event: VÝROČNÍ KONFERENCE ČESKÉ AEROSOLOVÉ SPOLEČNOSTI /22./, Čeladná (CZ), 20231113
Year: 2023
Language: eng
Abstract: Pressurized metered dose inhalers (MDI) and dry powder inhalers (DPI) are an integral part of the treatment of lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) (Vichrow et al., 2008). An important characteristic of particles dosed by MDI and DPI is particle size distribution (PSD) (Byron, 1990). This may vary depending on the formulation, but also on the temperature and relative humidity (RH) changes during the transport from the inhaler to the human respiratory tract. The aim of this study was to determine the influence of RH and inspiratory flow rates on the PSD\ncharacteristics and predict deposition efficiency of inhalable particles in the lungs.
Keywords: hygroscopicity; inhaler; number size distribution
Project no.: LTC17010, MP1404 (CEP)
Funding provider: GA MŠk
Host item entry: SBORNÍK XXII. VÝROČNÍ KONFERENCE ČESKÉ AEROSOLOVÉ SPOLEČNOSTI, ISBN 978-80-908653-1-0
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.

Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: https://hdl.handle.net/11104/0348681

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