Original title: Vliv mikronizovaného poloxameru na sypnost a lisovatelnost modelové tabletoviny
Translated title: The influence of micronized poloxamer on the flow and compaction of a model tableting mixture
Authors: Dunlap, Brooke Alexandra ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Document type: Rigorous theses
Year: 2023
Language: eng
Abstract: Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. Zdenka Šklubalová, Ph.D. Consultant: Sebastien Bailey Student: Brooke Alexandra Dunlap Title of Thesis: The influence of micronized poloxamer on the flow and compaction of a model tableting mixture Lubricants are an important excipient used in the production of tablets, they facilitate powder flow during manipulation, prevent powder sticking to the press during compression, and aid in tablet ejection. In this thesis the effect of four different concentrations 0.5, 1.0, 1.5, and 2.0 % w/w of micronized Poloxamer 188 on a model tableting mixture consisting of a 1:1 ratio of Microcrystalline Cellulose (MCC) and Lactose (L) was tested to determine its effectiveness as a lubricant for tablet manufacturing. Flow through an orifice, angle of repose, Hausner ratio, compressibility index, dynamics of consolidation, and powder bed porosity were tested. There was no increase in flowability of the powder at any concentration of P188 in any test used, all mixtures showed poor or very poor flow behaviour. Compression process was evaluated according to the force displacement method at three different compression forces (5 kN, 7 kN, 10 kN) and special attention was paid to ejection force. P188 is an...
Keywords: compressibility; excipients; flowability; lubricants; tablets; lisovatelnost; lubrikanty; pomocné látky; sypnost; tablety

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/187070

Permalink: http://www.nusl.cz/ntk/nusl-537575


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Rigorous theses