Mikroskopická stavba střevních anastomóz a užití zvířecích modelů v experimentální chirurgii střeva

Kural, Tomáš

Despite extensive research and the implementation of modern surgical methods, the incidence of anastomotic leaks remains high. The exact pathophysiological mechanisms responsible for these leaks are still unknown, making prevention a challenge. The use of animal models is extensive in the research of intestinal anastomotic leakage. The literature review of this thesis, therefore, presents a brief history of the usage of experimental animals as well as major differences in terms of anatomy and histology between humans and the experimental mammals utilized in intestinal healing studies. The thesis is based on four studies describing the possibilities of using quantitative histological methods in different applications, animal models, and experimental surgical techniques in the research of intestinal anastomotic healing. The conclusions of these four studies can be summarized as follows: Conclusion 1: TeIGen software is readily accessible to scientists researching fibrous and porous materials using micro-CT analysis. This software aids in producing virtual image sets with defined morphometric attributes, and it can also help with fine-tuning of quantification tools required to examine micro-CT scans. The software also enables the identification of material morphological properties and image...

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