Original title: Comparison of Pharmacokinetic Models for Quantification of Blood-Brain-Barrier Opening Induced by Focused Ultrasound
Authors: Hývlová, Denisa ; Vitouš, Jiří ; Jiřík, Radovan
Document type: Papers
Language: eng
Publisher: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstract: This paper focuses on quantification of blood-brainbarrier(BBB) opening induced by focused ultrasound. Dynamiccontrast-enhanced MRI (DCE-MRI) with two different pharmacokineticmodels, 2CX and ETK, is used to evaluate BBB opening.The ETK model is commonly used in BBB-opening studies. Wepropose use of a more advanced model, 2CX, that provides moreaccurate estimation of the BBB permeability. The accuracy of themodels is compared using simulated and real data. The resultsdemonstrate similar performance of the 2CX and ETK models inthe brain region with a highly permeable BBB, but the ETK hasproven unable to correctly detect low level of permeabilization.Thus, the 2CX model is more suitable for the studies of BBBpermeabilitydynamics.
Keywords: BBB opening; DCE-MRI; focusedultrasound; perfusion analysis; simulation
Host item entry: Proceedings II of the 29st Conference STUDENT EEICT 2023: Selected papers, ISBN 978-80-214-6154-3, ISSN 2788-1334

Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: http://hdl.handle.net/11012/210674

Permalink: http://www.nusl.cz/ntk/nusl-531780


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