Zabránění stárnutí buněk in vitro

Kubovčák, Matej

This bachelor thesis explores foundational components of the aging process and their importance in cell culture systems. Signaling pathways controlling these processes are discussed, and several attractive targets were identified to be potentially developed as interventions. Aging is described within the evolutionary paradigm to provide a global framework for understanding the various aging processes and their explanation. Several models in nature were found to provide evidence that aging interventions can be successful and could therefore serve as a source of inspiration. Immunological context is provided to underline its importance in vivo, and the immune system-specific longevity mechanisms are elucidated for potential exploitation. Loss of cellular identity is identified as an essential detrimental factor in cell culture and is connected to the foundational aging mechanisms. This thesis can serve as a stepping stone for conducting research on better cultivation methodologies, thereby opening doors to technologies such as cultivated meat and bioartificial organs requiring unprecedented cell expansion. Keywords aging, aging reversal, cellular identity, in vitro cultures, stemness

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