Original title: Chiral anion exchanger based on α-methylbenzylamine for enantioselective separation of racemic acids
Authors: Čížek, Jan
Document type: Papers
Conference/Event: Bažant postraguate conference 2023, Prague (CZ), 20230531
Year: 2023
Language: eng
Abstract: In this work, new enantioselective material based on α-methylbenzylamine as the chiral selector (recently utilized by our group in the preparation of chiral\nmembranes) covalently attached to Merrifield resin beads is proposed and discussed as a potentially cost-effective alternative to typically expensive stationary phase materials. It is shown that charged chiral methylbenzylamine works as an enantioselective anion exchanger potentially suitable for the separation of chiral acids, such as N–protected amino acid, or non-steroidal anti-inflammatory drugs (NSAID), such as ibuprofen. In a glass column chromatography experiment, racemic N–(tert–butoxycarbonyl) tryptophan was partially separated, reaching enantiomeric excess in eluates of around 10%.\n
Keywords: chiral membranes; racemic acids; separation
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-29-0
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.

Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: https://hdl.handle.net/11104/0343255

Permalink: http://www.nusl.cz/ntk/nusl-526206


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