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Original title:
Organoruthenium glycomimetics as selective galectin-1 inhibitors
Authors: Hamala, Vojtěch
Document type: Papers
Conference/Event: Bažant postraguate conference 2023, Prague (CZ), 20230531
Year: 2023
Language: eng
Abstract: The prepared organoruthenium glycomimetics demonstrated sin gle unit nanomolar affinity to Gal-1 and over four orders of magnitude\nhigher selectivity to Gal-1 in comparison to Gal-3. The organoruthe nium galectin inhibitors were found to be nontoxic to both cancer and\nnoncancerous cell lines. Selected complexes showed an in vitro an timigratory effect against invasive cancer cell lines MDA-MB-231 and\nSK-OV-3.
Keywords: carbohydrates; galectin inhibitors; glycomimetcs
Project no.: GA23-06115S (CEP)
Funding provider: GA ČR
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-29-0
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.
Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: https://hdl.handle.net/11104/0343241
Permalink: http://www.nusl.cz/ntk/nusl-526201
The record appears in these collections:
Research > Institutes ASCR > Institute of Chemical Process Fundamentals
Conference materials > Papers
Authors: Hamala, Vojtěch
Document type: Papers
Conference/Event: Bažant postraguate conference 2023, Prague (CZ), 20230531
Year: 2023
Language: eng
Abstract: The prepared organoruthenium glycomimetics demonstrated sin gle unit nanomolar affinity to Gal-1 and over four orders of magnitude\nhigher selectivity to Gal-1 in comparison to Gal-3. The organoruthe nium galectin inhibitors were found to be nontoxic to both cancer and\nnoncancerous cell lines. Selected complexes showed an in vitro an timigratory effect against invasive cancer cell lines MDA-MB-231 and\nSK-OV-3.
Keywords: carbohydrates; galectin inhibitors; glycomimetcs
Project no.: GA23-06115S (CEP)
Funding provider: GA ČR
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-29-0
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.
Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: https://hdl.handle.net/11104/0343241
Permalink: http://www.nusl.cz/ntk/nusl-526201
The record appears in these collections:
Research > Institutes ASCR > Institute of Chemical Process Fundamentals
Conference materials > Papers
Record created 2023-06-18, last modified 2023-12-11
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