Original title: Deoxyfluorinated N-acetyllactosamines as carbohydrate-based probes for human galectins
Authors: Kurfiřt, Martin
Document type: Papers
Conference/Event: Bažant Postgraduate Conference 2022, Prague (CZ), 20220613
Year: 2022
Language: eng
Abstract: This work is focused on a detailed NMR investigation of human galectins via a complete series of mono-deoxyfluorinated Nacetyllactosamine probes 1–6, which were prepared previously in our laboratory.3 Advanced 19F NMR T2-filter technique enabled the identification of hydroxyl groups essential for the interaction with varioushGals, and permitted to compare hGals in terms of the importance of these key hydroxyl groups in the recognition events. Furthermore, the library was also investigated by various NMR techniques such as 19F EXSY, STD and 15N CSP to reveal the molecular origin of recognition events.\n
Keywords: human galectins; NMR techniques; selective inhibitors
Project no.: LTC20052, GA20-01472S (CEP), CA18103
Funding provider: GA MŠk, GA ČR
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-24-5
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.

Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: http://hdl.handle.net/11104/0332200

Permalink: http://www.nusl.cz/ntk/nusl-508660


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