Original title: Nové modifikované 7-deazapurinové báze a nukleosidy
Translated title: New modified 7-deazapurine bases and nucleosides
Authors: Krömer, Matouš ; Hocek, Michal (advisor) ; Smrček, Stanislav (referee)
Document type: Master’s theses
Year: 2015
Language: cze
Abstract: [cze] [eng]
Byly navrženy tři cesty pro syntézu 5'-deoxy a 5'deoxy-5'-fluormodifikovaných nukleosidů odvozených od známých cytostatických látek. Dvě cesty byly úspěšně završeny přípravou cílových látek. Poslední cesta nebyla úspěšná kvůli problémům s odchráněním klíčového intermediátu. The three ways of synthesis of 5'-deoxy and 5'deoxy-5'-fluoromodified nucleosides derived from known cytostatic compounds was designed. Two routes were successfully developed and target substances were prepared. Third one was unsuccessful due to difficulties with deprotection of the key intermediate.
Keywords: C-H activations; cross-couplings; deazapurines; nucleobases; nucleosides; C-H aktivace; cross-coupling; deazapuriny; nukleobáze; nukleosidy

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/79069

Permalink: http://www.nusl.cz/ntk/nusl-496922


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses