Original title: Pyridine-N-oxide analogue of DOTA as a building block for MRI contrast agents
Translated title: Pyridine-N-oxide analogue of DOTA as a building block for MRI contrast agents
Authors: Polášek, Miloslav ; Hermann, Petr (advisor) ; Geraldes, Carlos F. G. C. (referee) ; Botta, Mauro (referee) ; Marek, Radek (referee)
Document type: Doctoral theses
Year: 2009
Language: cze
Abstract: Conclusions In my PhD project I synthesized two new polydentate macrocyclic ligands, the monofunctional DO3A-pyNO and the bifunctional DO3A-pyNO-C. Both compounds are based on the design of DOTA, with one of the acetate pendant arms being replaced with a pyridine-Noxide arm. This structural modification has a tremendous influence on chemical properties of the lanthanide(III) complexes of these compounds. The water exchange rate in the gadolinium(III) complexes is significantly accelerated in comparison with the complexes of DOTA. In fact, the values are almost optimal for use of the Gd(III) complexes as contrast agents for magnetic resonance imaging. Besides, the complexes exist exclusively in the form of square antiprismatic isomers. I investigated the complexes by various physico-chemical techniques in solution and in solid state, in order to elucidate the relationship between their structure and properties. On the basis of these results I found an explanation to the unexpectedly fast water exchange rate observed on the squareantiprismatic isomers. I established a synthetic protocol that can be used for the attachment of the bifunctional ligand DO3A-pyNO-C to any amine-bearing molecule. I prepared a series of conjugates with polyamidoamine dendrimes and a conjugate with per-6-amino--cyclodextrine and...

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/19932

Permalink: http://www.nusl.cz/ntk/nusl-484363


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses