Syntéza derivátů karboxyxanthonu jako stavebních bloků pro enantiomerně čisté sloučeniny. Syntéza a stanovení struktury derivátů xanthonu (XD) 2-karboxy-6-methoxyxanthonu (XD-2)

Heczková, Jana

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate Jana Heczková Consultant Professora Doutora Madalena Maria de Magalhães Pinto, Assoc. Prof. RNDr. Veronika Opletalová, Ph.D. Title of Thesis Synthesis of carboxyxanthone derivatives as building blocks for enantiomeric pure compounds. Synthesis and structure elucidation of xanthone derivative (XD) 2-carboxy-6-methoxyxanthone (XD-2) The importance of xanthone derivatives is considerable. They possess large variety of biological and pharmacological activities. Many of them proved to be important building blocks for synthesis of new compounds. Chirality is a fundamental property of biological systems and reflects the underlying asymmetry of matter. Almost one-third of all drug sales worldwide are chiral compounds and the authorities recommend that the chiral drugs should be saled in pure enantiomeric forms because enantiomers may differ both quantitatively and qualitatively in their biological activities. At one extreme, one enantiomer may be devoid of any biological activity; at the other extreme, both enantiomers may have qualitatively different biological activities. Enantiomers also differ in bioavailability - one enantiomer can be more bioavailable than the other,...

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