Úloha mikroRNA ve fyziologii a patologii

Janáková, Barbora

Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Mgr. Barbora Hanousková Supervisor: doc. Ing. Petra Matoušková, Ph.D. Title of Doctoral Thesis: The role of microRNA in physiology and pathology MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that play an important role in the regulation of gene expression. They are evolutionarily highly conserved and are present in the genome of all eukaryotic organisms, suggesting their importance in physiological processes. Due to the tissue specificity and their involvement in the pathogenesis of various diseases, miRNAs have been widely studied in connection with their potential use as specific and early biomarkers, or as a therapeutic target. The doctoral thesis, written in the form of an annotated set of publications, dealt with the study of miRNAs in various systems in vitro and in vivo, focusing on their role in adipogenesis and their use as biomarkers of pathological conditions. The introduction summarizes the theoretical information on epigenetic regulation with a more detailed focus on miRNAs, followed by comments on the author's individual publications and brief conclusions. In two studies using mouse models, several miRNAs were identified to have their expression profile...

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