Experimentální stanovení fotodynamické účinnosti derivátů ftalocyaninů a stanovení buněčné smrti.

Hlbočanová, Ingrid

Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Science Candidate: Ingrid Hlbočanová Supervisor: RNDr. Miloslav Macháček, Ph.D. Title of bachelor thesis: Experimental evaluation of photodynamic efficiency of phthalocyanine photosenzitisers and cell death assessment Tumor diseases represent on of the largest group of malignant illnesses in the world. Their incidence is slowly shifting from developed countries to third world countries and therefore they represent the most widespread health problems, often leading to the death of patients. Intensive research and development of new and effective anticancer drugs and treatment methods is devoted because of the spread and mortality of these diseases. One of the intensively researched modern method is photodynamic therapy (PDT), which is utilizing photosenzitizers (PSs). To ensure the maximum efficiency, effectiveness of PDT and maximalization of results, it is necessary to observe three basic parameters - effective PS, light and oxygen. These individual components do not represent danger to the patients on their own, but their combination brings positive effect in the cancer treatment. The principle of the method is administration of an inactive PS to the patient with subsequent irradiation by light of suitable...

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