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Original title:
Studium vlivu hydrofilního nosiče na rychlost rozpouštění léčiva ze skupiny BCSII
Translated title: Study of influence of a hydrophilic carrier on the dissolution rate of the BCS II drug
Authors: Bunes, Andrea Suther ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Document type: Master’s theses
Year: 2021
Language: eng
Abstract: Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. PharmDr. Zdenka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Andrea Suther Bunes Title of Thesis: Study of influence of hydrophilic carriers on the dissolution rate of a BCS II drug The aim of this thesis was to study the effect of mixing and co-milling with hydrophilic carriers on the dissolution rate of a model BCS II drug meloxicam. The mixtures of two different drug loads (1-1, 1-8) were characterized for granulometric and dissolution parameters. USP-4 apparatus assembled with a flow-through powder cell (an open loop) was used to estimate meloxicam relative dissolution rate rrel (min-1 ). Mixing with lactose, particularly in a higher ratio, increased the relative dissolution rate in comparison to the pure meloxicam. The effect was further increased by co-milling, but an unfavourable event of agglomeration occurred, especially for the 1-1 drug-excipient ratio sample. Adding chitosan solved this problem due to the formation of interactive mixture. The co-milled sample containing chitosan and lactose in a 1-8 ratio showed the highest rrel = 0.48 min-1 .
Keywords: carrier; dissolution; milling; mixing; solubility
Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/126378
Permalink: http://www.nusl.cz/ntk/nusl-446240
The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses
Translated title: Study of influence of a hydrophilic carrier on the dissolution rate of the BCS II drug
Authors: Bunes, Andrea Suther ; Šklubalová, Zdeňka (advisor) ; Vraníková, Barbora (referee)
Document type: Master’s theses
Year: 2021
Language: eng
Abstract: Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. PharmDr. Zdenka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Andrea Suther Bunes Title of Thesis: Study of influence of hydrophilic carriers on the dissolution rate of a BCS II drug The aim of this thesis was to study the effect of mixing and co-milling with hydrophilic carriers on the dissolution rate of a model BCS II drug meloxicam. The mixtures of two different drug loads (1-1, 1-8) were characterized for granulometric and dissolution parameters. USP-4 apparatus assembled with a flow-through powder cell (an open loop) was used to estimate meloxicam relative dissolution rate rrel (min-1 ). Mixing with lactose, particularly in a higher ratio, increased the relative dissolution rate in comparison to the pure meloxicam. The effect was further increased by co-milling, but an unfavourable event of agglomeration occurred, especially for the 1-1 drug-excipient ratio sample. Adding chitosan solved this problem due to the formation of interactive mixture. The co-milled sample containing chitosan and lactose in a 1-8 ratio showed the highest rrel = 0.48 min-1 .
Keywords: carrier; dissolution; milling; mixing; solubility
Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/126378
Permalink: http://www.nusl.cz/ntk/nusl-446240
The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses
Record created 2021-06-27, last modified 2023-12-31