Original title: REGULATORY NETWORK OF DRUG-INDUCED ENZYME PRODUCTION: PARAMETER ESTIMATION BASED ON THE PERIODIC DOSING RESPONSE MEASUREMENT
Authors: Papáček, Štěpán ; Lynnyk, Volodymyr ; Rehák, Branislav
Document type: Papers
Conference/Event: Programy a algoritmy numericke matematiky 2020 (PANM 2020), Hejnice (CZ), 20200621
Year: 2021
Language: eng
Abstract: The common goal of systems pharmacology, i.e. systems biology applied to the eld of pharmacology, is to rely less on trial and error in designing an input-output systems, e.g. therapeutic schedules. In this paper we present, on the paradigmatic example of a regulatory network of drug-induced enzyme production, the further development of the study published by Duintjer Tebbens et al. (2019) in the Applications of Mathematics. Here, the key feature is that the nonlinear model in form of an ODE system is controlled (or periodically forced) by an input signal being a drug intake. Our aim is to test the model features under both periodic and nonrecurring dosing, and eventually to provide an innovative method for a parameter estimation based on the periodic dosing response measurement.
Keywords: Dynamical system; FFT; Input-output; Parameter estimation; Regulation; Regulatory network
Project no.: GA19-05872S (CEP)
Funding provider: GA ČR
Host item entry: Programs and Algorithms of Numerical Mathematics. Proceedings of Seminar, ISBN 978-80-85823-71-4

Institution: Institute of Information Theory and Automation AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: http://library.utia.cas.cz/separaty/2021/TR/papacek-0542303.pdf
Original record: http://hdl.handle.net/11104/0320101

Permalink: http://www.nusl.cz/ntk/nusl-438869


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