Original title: Hodnocení strukturální a funkční konektivity u pacientů s Parkinsonovou nemocí
Translated title: Structural and functional connectivity assessment in patients with Parkinson's disease
Authors: Klobušiaková, Patrícia ; Keller, Jiří (referee) ; Mekyska, Jiří (advisor)
Document type: Bachelor's theses
Year: 2020
Language: slo
Publisher: Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií
Abstract: [slo] [eng]
Skoré zmeny vo vizuospaciálnych funkciách predikujú demenciu u pacientov s Parkinsonovou chorobou (PD). Cieľom tejto práce je porovnať štrukturálnu a funkčnú konektivitu traktu fasciculus longitudinalis inferior (ILF), ktorý je zapojený do spracovania vizuospaciálnych informácií, u PD pacientov v porovnaní so zdravými kontrolami, a nájsť asociácie medzi zmenami konektivity a kognitívnym výkonom v pacientských skupinách s miernou kognitívnou poruchou (MCI) alebo bez nej. Pre splnenie nášho zámeru sme nabrali dáta od PD pacientov bez kognitívneho deficitu (PD-NC, n = 23) , PD pacientov s MCI (PD-MCI, n = 21) a zdravých kontrol (HC, n = 48). Obojsmerná iteratívna parcelácia bola použitá na izoláciu traktov ILF a ich špecifických endpointov (lobus occipitalis a lobus temporalis anterior) u každého subjekta. Endpointy ďalej slúžili ako oblasti záujmu pre výpočet funkčnej konektivity. V PD-MCI skupine sme našli zníženie mikroštrukturálnej konektivity kvantifikované parametrami priemerná difuzivita, frakčná anizotropia a radiálna difuzivita. Okrem toho, funkčná konektivita traktov ILF bola znížená už u skupiny PD-NC. Porucha štrukturálnej aj funkčnej konektivity bola spojená so zhoršením vizuospaciálnych funckií u PD-MCI. Tieto zmeny by mohli slúžiť ako potenciálne markery priebehu choroby alebo pre monitorovanie efektu liečby. Early changes in visuospatial functions predict dementia in Parkinson’s disease (PD). The aim of this work is to assess both structural and functional connectivity of the fasciculus longitudinalis inferior (ILF), which is engaged in visuospatial processing, in PD patients in comparison to healthy controls, and to find associations between connectivity changes and cognitive performance in the patient groups with or without mild cognitive impairment (MCI). To achieve our goal we recruited PD patients with normal cognition (PD-NC, n = 23) and PD with MCI (PD-MCI, n = 21) as well as healthy controls (HC, n = 48). Bidirectional iterative parcellation was used to isolate ILF tracts and their respective endpoints (occipital lobe and anterior temporal lobe) in each subject. The endpoints then served as regions of interest for functional connectivity calculation. We found ILF microstructural connectivity impairment in PD-MCI group, as measured by mean diffusivity, fractional anisotropy and radial diffusivity. In addition, the functional connectivity of ILF tracts was decreased already in the PD-NC. Both structural and functional connectivity deterioration was associated with visuospatial dysfunction in PD-MCI. These changes could serve as potential markers of disease progression or treatment effects monitoring.
Keywords: Bidirectional Iterative Parcellation; connectivity; fMRI; inferior longitudinal fasciculus; Parkinson’s disease

Institution: Brno University of Technology (web)
Document availability information: Fulltext is available in the Brno University of Technology Digital Library.
Original record: http://hdl.handle.net/11012/190461

Permalink: http://www.nusl.cz/ntk/nusl-413608


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Universities and colleges > Public universities > Brno University of Technology
Academic theses (ETDs) > Bachelor's theses