Original title: In vitro and in vivo studies of the neuroprotective peptide humanin using 125I-radiolabeled humanin derivatives
Authors: Evangelou, A. ; Zikos, C. ; Benaki, D. ; Pelecanou, M. ; Bouziotis, P. ; Papadopoulos, M. ; Borovičková, Lenka ; Veselá, Iva ; Elbert, Tomáš ; Kunešová, G. ; Pirmettis, I. ; Paravatou-Petsotas, M. ; Slaninová, Jiřina ; Livaniou, E.
Document type: Papers
Conference/Event: Biologically Active Peptides. Conference /11./, Praha (CZ), 2009-04-22 / 2009-04-24
Year: 2009
Language: eng
Abstract: Four new HN-derivatives were synthesized: Y-PAGASRLLLTGEIDLP (Y-des-Leu-RG-PAGA, 1), Y-PAGASRLLLLTGEIDLP (Y-RG-PAGA, 2), Y-SALLRSIPAPAGASRLLLTGEIDLP (Y-des-Leu-Colivelin, 3), Y-SALLRSIPAPAGASRLLLLTGEIDLP (Y-Colivelin, 4), their neuroprotective action was evaluated in the T-maze test and the most active ones were monoradioiodinated with 125I and the labelled peptides used for binding and biodistribution studies.
Keywords: 125I-radiolabeled derivatives; humanin; in vitro binding; neuroprotective peptides
Project no.: CEZ:AV0Z40550506 (CEP)
Host item entry: Biologically Active Peptides. 11th Conference, ISBN 978-80-86241-31-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0181961

Permalink: http://www.nusl.cz/ntk/nusl-41211


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers