Original title: Benigní helmint Hymenolepis diminuta pozitivně ovlivňuje chemicky vyvolanou kolitidu u potkaního modelu
Authors: LEVÁ, Jana
Document type: Rigorous theses
Year: 2019
Language: eng
Abstract: In this study is examined the protective effect of different life cycles stages of rat tapeworm Hymenolepis diminuta against dinitrobenzene sulphonic acid (DNBS) induced colitis in rat model. The clinical health of rats, gut microbiota and systemic inflammation was analysed. For determination of the level of inflammation and type 2 immune response of rat model was used relative gene expression of TNF, IL-1, IL-4, IL-13 and IL-10 using real-time PCR. Our results showed that colonization by immature life stages of H. diminuta before the induction of DNBS colitis reduced clinical symptoms and inflammation in rat model but did not protect rats against colitis. Type 2 immune response was detected by an increase in gene expression of IL-4, IL-10 and IL-13. The gut microbiota does not substantial role in H. diminuta-mediated protection.
Keywords: cytokines; DNBS colitis; gut microbiota; helminth; helminth therapy; Hymenolepis diminuta; IL-10
Citation: LEVÁ, Jana. Benigní helmint Hymenolepis diminuta pozitivně ovlivňuje chemicky vyvolanou kolitidu u potkaního modelu. České Budějovice, 2019. rigorózní práce (RNDr.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/58895

Permalink: http://www.nusl.cz/ntk/nusl-403738


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Rigorous theses