National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Imunomodulační účinky extraktů z helminta na střevní buněčnou linii potkaního modelu
LEVÁ, Jana
In this study, we examined the immunomodulatory effect of excretory/secretory products, crude adult extracts and crude larvae extracts from Hymenolepis diminuta on the intestinal epithelilal cell line from a rat. For determination of the immunomodulation effect of all H. diminuta extracts was used relative gene expression of TNFa, IL-17re and IL-33 from epithelial cells and it was tested using real-time PCR. Our result showed that excretory/secretory products had the strongest antiinflammatory effect on the epithelial cells. We assume that crude adult extracts play an important role in increase of gene expression of IL-33 and also in the immunomodulatory ability of H. diminuta in the host organism.
Sledování změn genové exprese interleukinu 10 u potkana jako modelového organizmu v průběhu infekce tasemnicí \kur{Hymenolepis diminuta}
LEVÁ, Jana
In this study, we examined the gene expression of interleukin 10 (IL-10) mobilized by rats during prepatent and patent period of Hymenolepis diminuta infection. Relative IL-10 gene expression was determined from blood samples using real-time PCR. Our results showed that IL-10 gene expression is significantly increased in the begining of the prepatent period of H. diminuta infection in the rat model system.

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