Original title: The effect of low dose of vinclozolin on reproductive tract development in CD1 outbred mice
Authors: Pěknicová, Jana ; Elzeinová, Fatima ; Nováková, Vendula ; Buckiová, Daniela ; Kubátová, Alena
Document type: Papers
Conference/Event: 3. český a mezinárodní andrologický kongres, Štiřín (CZ), 2008-06-13 / 2008-06-15
Year: 2008
Language: eng
Abstract: The effect of a low dose of vinclozolin within the development of the reproductive tract during gestation (VIN-GD 15-22) and puberty (VIN-PND 23-44) in CD1 mice was tested. We found a decrease in the anogenital distance, prostate weight and pathology of testes in both experimental groups. Sperm counts decreased to 46% (VIN-GD) and to 81% (VIN-PND), and also the acrosomal state (evaluated by antiacrosomal antibody) decreased in both groups to 89% in comparison to the control group (100%). Sperm head abnormalities increased by approximately 18% and 13%, respectively. In this connection, the expression of some genes was changed (arosome-related gene (Acr), apoptosis related genes (p53, p21)). In conclusion, a low dose of vinclozolin affected the reproductive tract, sperm parameters and expression of selected genes in both experimental groups.
Keywords: spermatozoa; vinclozolin
Project no.: CEZ:AV0Z50520701 (CEP), 1M0611 (CEP), 2B06151 (CEP)
Funding provider: GA MŠk, GA MŠk
Host item entry: European Andrology - 3. český a mezinárodní andrologický kongres, ISSN 1802-4793

Institution: Institute of Biotechnology AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0171316

Permalink: http://www.nusl.cz/ntk/nusl-40069


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