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Original title:
Vliv endokrinních disruptorů na reprodukci savců
Translated title: Effect of endocrine disruptors on mammalian fertility
Authors: Pěknicová, Jana ; Nováková, Vendula ; Buckiová, Daniela ; Boubelík, Michael ; Elzeinová, Fatima ; Kubátová, Alena
Document type: Papers
Conference/Event: Sjezd českých a slovenských alergologů a klinických imunologů /25./ a Kongres českých a slovenských imunologů s mezinárodní účastí /12./, Praha (CZ), 2008-10-29 / 2008-11-1
Year: 2008
Language: cze
Abstract: Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality.
Keywords: endocrine disruptor; phytoestrogen; sperm integrity; xenoestrogen
Project no.: CEZ:AV0Z50520701 (CEP), CEZ:AV0Z50390703 (CEP), CEZ:AV0Z50520701 (CEP), 1M06011 (CEP), OKDEQ OE211, 2B06151 (CEP)
Funding provider: GA MŠk, GA MŠk, GA MŠk
Host item entry: Alergie, ISSN 1212-3536
Institution: Institute of Biotechnology AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0171303
Permalink: http://www.nusl.cz/ntk/nusl-40064
The record appears in these collections:
Research > Institutes ASCR > Institute of Biotechnology
Conference materials > Papers
Translated title: Effect of endocrine disruptors on mammalian fertility
Authors: Pěknicová, Jana ; Nováková, Vendula ; Buckiová, Daniela ; Boubelík, Michael ; Elzeinová, Fatima ; Kubátová, Alena
Document type: Papers
Conference/Event: Sjezd českých a slovenských alergologů a klinických imunologů /25./ a Kongres českých a slovenských imunologů s mezinárodní účastí /12./, Praha (CZ), 2008-10-29 / 2008-11-1
Year: 2008
Language: cze
Abstract: Endocrine system is one of the most important regulatory systems in the mammalian body. The endocrine disruptors (ED) can disrupt the function of the endocrine system but their activity is not a result of the physiological regulation. The effect of low dose of selected ED, bisphenol-A (BPA), p-nonylphenol (NP), diethylstilbestrol (DES), genistein (GEN), resveratrol (RES)), hormone (17α-ethynylestradiol (EE2)) and polybrominated compound (tetrabromobisphenol A (TBBPA)) within development of reproductive tract in outbred CD1 mice was tested. BPA and NP had a negative effect on reproductive organs morphology and mouse spermatozoa. The fertility of mice exposed to DES was disrupted. Contrary to that, treatment by GEN and RES had no effect on the fertility of mice but had some effect on their reproductive parameters except for sperm integrity. Synthetic hormone (EE2) and polybrominated compound (TBBPA) also affected on the organ weight, reproductive parameters and sperm quality.
Keywords: endocrine disruptor; phytoestrogen; sperm integrity; xenoestrogen
Project no.: CEZ:AV0Z50520701 (CEP), CEZ:AV0Z50390703 (CEP), CEZ:AV0Z50520701 (CEP), 1M06011 (CEP), OKDEQ OE211, 2B06151 (CEP)
Funding provider: GA MŠk, GA MŠk, GA MŠk
Host item entry: Alergie, ISSN 1212-3536
Institution: Institute of Biotechnology AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0171303
Permalink: http://www.nusl.cz/ntk/nusl-40064
The record appears in these collections:
Research > Institutes ASCR > Institute of Biotechnology
Conference materials > Papers
Record created 2011-07-01, last modified 2024-01-26