Original title: Reduction of the DNA at a Pyrolytic Graphite Electrode:Opening of the Second Half of the Potential Window
Authors: Špaček, Jan ; Daňhel, Aleš ; Hasoň, Stanislav ; Hejduková, M. ; Fojta, Miroslav
Document type: Papers
Conference/Event: Moderní elektrochemické metody /38./, Jetřichovice (CZ), 20180521
Year: 2018
Language: eng
Abstract: The pyrolytic graphite electrode (PGE) can be used at highly negative potentials, providing reduction signals known from mercury-based electrodes. Use of the negative part of the potential window more than doubled the number of analytically useful signals provided by unlabelled DNA on PGE. It enables selective analysis of all canonical DNA bases,5-methylcytosine and uracil It also allows for distinction of overlapping signals cathodic polarization can selectively ´switch off´ DNA anodic signals and rice versa. Newly observed signals corresponding to oxidation of reduced bases and reduction of oxidized bases are also described.
Keywords: 5-Methyleylosine; dna; Electrochemical oxidation; Electrochemistry
Project no.: GA16-01625S (CEP), EF15_003/0000477
Funding provider: GA ČR, GA MŠk
Host item entry: XXXVIII. Moderní elektrochemické metody. Sborník přednášek, ISBN 978-80-905221-6-9

Institution: Institute of Biophysics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0297814

Permalink: http://www.nusl.cz/ntk/nusl-396391


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Research > Institutes ASCR > Institute of Biophysics
Conference materials > Papers