Original title: Synthesis of 8-C-substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-couplin
Translated title: Příprava 8-C-substituovaných acyklických nukleosidfosfonátů odvozených od 2,6 diaminopurinu s využitím Negishiho cross-couplingu
Authors: Sedláček, Ondřej ; Pohl, Radek ; Holý, Antonín
Document type: Papers
Conference/Event: Symposium on Chemistry of Nucleic Acid Components /14./, Český Krumlov (CZ), 2008-06-08 / 2008-06-13
Year: 2008
Language: eng
Abstract: [eng] [cze]
8-Allyl-, cyclopropyl-, trifluoromethyl-, cyano-, carbethoxy- and acetaldehydo-2,6-diamino- 9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) were prepared by Negishi cross-coupling of the 8-bromo-PMEDAP under catalysis with Pd2dba3 with various phosphine ligands followed by deprotection. 8-Allyl-, cyklopropyl-, trifluoromethyl-, kyano-, karbethoxy- and acetaldehydo-2,6-diamino- 9-[2-(fosfonomethoxy)ethyl]purin (PMEDAP) byly připraveny pomocí Negishiho cross-couplingu z 8-brom-PMEDAPu za katalýzy Pd2dba3 s různými fosfinovými ligandy a jeho následnou deprotekcí.
Keywords: 2,6-diaminopurine; 8-C-substituted; acyclic nucleoside phosphonates; Negishi cross-coupling
Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1QS400550501 (CEP), 1UC1A1062540-01
Funding provider: GA MŠk, GA AV ČR, NIH
Host item entry: Chemistry of Nucleic Acid Components, ISBN 978-80-86241-29-6

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0162026

Permalink: http://www.nusl.cz/ntk/nusl-38986


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