Original title: Metalation of 6-halo-2,4-dimethoxypyrimidines as the key step for the synthesis of biologicaly active compounds
Translated title: Metalace 6-halo-2,4-dimethoxypyrimidinů jako klíčový krok pro syntézu biologicky aktivních sloučenin
Authors: Nencka, Radim ; Hřebabecký, Hubert ; Votruba, Ivan ; Dračínský, Martin ; Holý, Antonín
Document type: Papers
Conference/Event: Symposium on Chemistry of Nucleic Acid Components /14./, Český Krumlov (CZ), 2008-06-08 / 2008-06-13
Year: 2008
Language: eng
Abstract: [eng] [cze]
Introduction of carbon substituents to the position C-5 and C-6 of uracil ring was performed by reaction of organometallic derivatives of uracil with electrophiles or by transition metal catalyzed cross-coupling reaction. Especially lithiathion was studied intensively. Zavedení uhlíkatých substituentů do polohy C-5 a C-6 na uracilovém kruhu bylo provedeno reakcí organokovových derivátů uracilu s elektrofily nebo cross-couplingem. Hlavní pozornost byla věnována lithiacím.
Keywords: cross-coupling; lithiation; organometallic; pyrimidine
Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1QS400550501 (CEP)
Funding provider: GA MŠk, GA AV ČR
Host item entry: Chemistry of Nucleic Acid Components, ISBN 978-80-86241-29-6

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0161994

Permalink: http://www.nusl.cz/ntk/nusl-38977


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers