Original title:
Inkluze osob se zdravotním postižením do projektů české zahraniční rozvojové spolupráce
Translated title:
Inclusion of persons with disabilities into projects of Czech development cooperation
Authors:
Janušová, Nela ; Novotný, Josef (advisor) ; Komanická, Daniela (referee) Document type: Master’s theses
Year:
2018
Language:
cze Abstract:
[cze][eng] Taxanes are cytostatic routinely used for the treatment of solid breast, ovarian, prostate, head and neck tumors and other types of tumors. Resistance of tumor cells to the effect of taxanes represents serious obstacle for the employment of taxanes in the treatment of tumors. This resistance can be associated, among other things, with lower rate of apoptosis induction in cancer cells or also with increased level of transporters transporting taxanes out of the cell. In this PhD thesis we tried: (1) to contribute to elucidation of the role of molecular mechanisms of apoptosis induction by taxanes in cells of human breast cancer. Specifically, it meant to contribute to elucidation of the role of initiator caspase -8 a - 9 and mainly of initiator caspase-2. Next, to contribute to elucidation of the role of executioner caspase -3 - 6, and -7 and selected proteins of the Bcl-2 family. (2) To contribute to elucidation of molecular mechanisms of resistance of human breast cancer cells to taxanes. Specifically, it meant to describe the role of selected functional groups in taxane structure in bringing about and overcoming resistance to taxane and next to contribute to elucidation of the role of P-glycoprotein (ABCB1 transporter) in the resistance to individual taxanes. 1) We found that caspase-2 represents...This thesis deals with the issue of inclusion of persons with disabilities in development cooperation projects. The first part of this thesis justifies the importance of the chosen topic. Based on the sources available and their analyses, the thesis discusses concepts and approaches to the issue of inclusion of disabled people, which is also one of the declared cross-cutting principles of development cooperation. The objective of the empirical part was to find out whether and to what extent Czech non-profit organizations take into account disabled people in their projects. The empirical part uses qualitative methods of evaluation of eleven semi- structured interviews with employees of selected non-profit organizations. Also, the methods of conceptual analysis and short interviews with representatives of the Ministry of Foreign Affairs and the Czech Development Agency were used. The data gained imply that an inclusive approach is not applied universally, but depends on the project type or the organization. Smaller organizations either do not pay attention to the needs of persons with disabilities at all, or on the other hand, they work fully inclusively and take them into account even in projects where the primary goal is different. Larger organizations have a wide range of applications. They do not...
Institution: Charles University Faculties (theses)
(web)
Document availability information: Available in the Charles University Digital Repository. Original record: http://hdl.handle.net/20.500.11956/97897