Název:
The role of RNA-binding proteins in post-transcriptional gene regulation of Trypanosoma brucei
Autoři:
DIXIT, Sameer Typ dokumentu: Disertační práce
Rok:
2018
Jazyk:
eng
Abstrakt: This thesis characterizes RNA footprints of several RNA-binding proteins (RBPs) thatare involved in U-insertion/deletion, A-to-I, and C-to-U RNA editing in Trypanosoma brucei. Relying on iCLIP data and biochemical methods it shows that two paralogs proteins from the MRB1 complex regulate distinct editing fates of the mitochondrial transcripts. Further, this thesis provides evidence where the combinatorial interplay of RBPs might fine-tune the levels of edited mRNA. Finally, the presented thesis adds to the growing evidence of the importance of RBPs in post-transcriptional gene regulation.
Klíčová slova:
iCLIP; mitochondrial RNA biology; Post-trancriptional gene regulation; RNA editing Citace: DIXIT, Sameer. The role of RNA-binding proteins in post-transcriptional gene regulation of Trypanosoma brucei. České Budějovice, 2018. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Instituce: Jihočeská univerzita v Českých Budějovicích
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Informace o dostupnosti dokumentu:
Plný text je dostupný v digitálním repozitáři JČU. Původní záznam: http://www.jcu.cz/vskp/30994