Název:
A role of Sirt1 in the Notch signalling pathway.
Autoři:
HORVÁTH, Matej Typ dokumentu: Disertační práce
Rok:
2017
Jazyk:
eng
Abstrakt: The aim of this thesis was to examine role of Sirt1 in the Notch signalling pathway, using Drosophila as a model organism. Based on in vivo and in vitro studies, we conclude that Sirt1 plays a positive role in Notch signalling. In embryonic S2N cells, Sirt1 is responsible for the protection from metabolic stress-induced down-regulation of subset of E(Spl) genes. During development, Sirt1 is responsible for proper Notch-dependent specification of SOPs and wing development. Sirt1 can regulate the Notch signalling on multiple levels via deacetylation of various substrates involved in the Notch signalling revealed by our proteomic survey.
Klíčová slova:
Drosophila development; metabolic sensor; metabolic stress; Notch signalling; S2N cells; Sirt1 Citace: HORVÁTH, Matej. A role of Sirt1 in the Notch signalling pathway.. České Budějovice, 2017. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Instituce: Jihočeská univerzita v Českých Budějovicích
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Informace o dostupnosti dokumentu:
Plný text je dostupný v digitálním repozitáři JČU. Původní záznam: http://www.jcu.cz/vskp/21902