Original title: The mechanism of cytotoxicity of HPMA-based polymeric prodrugs depends on their intracellular pathway
Translated title: Mechanismus cytotoxicity polymerních léčiv založených na HPMA je závislý na jejich intracelulárním osudu
Authors: Hovorka, Ondřej ; Strohalm, Jiří ; Etrych, Tomáš ; Ulbrich, Karel ; Říhová, Blanka
Document type: Papers
Conference/Event: Annual Meeting of the European Society for Clinical Investigation /40./, Prague (CZ), 2006-03-15 / 2006-03-18
Year: 2006
Language: eng
Abstract: [eng] [cze]
Intracellular cleavage of doxorubicin is not a necessary prerequisite for the pharmacological activity of HPMA-based conjugates. Composition of the spacer bearing drug, and the way of doxorubicin binding strongly influences intracellular distribution of polymeric drugs and in that way the mechanism of cell death Intracelulární odštěpení doxorubicinu z polymerního konjugátu není nezbytnou podmínkou farmakologické aktivity polymerních konjugátů na bázi HPMA. Složení spojky nesoucí léčivo a způsob vazby doxorubicinu podstatně ovlivňuje intracelulární distribuci léčiva a tím pádem i mechanismus buněčné smrti
Keywords: doxorubicin; hpma; polymeric drugs
Project no.: CEZ:AV0Z50200510 (CEP), CEZ:AV0Z40500505 (CEP), GA305/05/2268 (CEP)
Funding provider: GA ČR
Host item entry: European Journal of Clinical Investigation

Institution: Institute of Microbiology AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0140257

Permalink: http://www.nusl.cz/ntk/nusl-36332


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Research > Institutes ASCR > Institute of Microbiology
Conference materials > Papers