Original title: Příprava a oxidativní coupling 1,5-disubstituovaných tetrazolů
Translated title: Synthesis and oxidative coupling of 1,5-disubstituted tetrazoles
Authors: Hrušková, Zuzana Rania ; Pour, Milan (advisor) ; Špulák, Marcel (referee)
Document type: Master’s theses
Year: 2013
Language: slo
Abstract: [eng] [cze]
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Zuzana Rania Hrušková Supervisor: Prof. RNDr. Milan Pour, PhD Title of diploma thesis: Preparation and oxidative coupling of 1,5-disubstituted tetrazoles. Following the established protocol developed for the preparation of 1,5-disubstituted tetrazoles employing Pd-catalyzed cross-coupling reactions with activated the C5-H bond we have been able to extend the existing library of tetrazoles. 1,5-Disubstituted tetrazoles were used as substrates for oxidative coupling reactions which would result to formation of tetrazolo[1,5-f]phenathridine core. However, all of the common methods we used for this reaction lead only to the traces of the desired product. Univerzita Karlova v Praze Farmaceutická fakulta v Hradci Králové Katedra anorganickej a organickej chémie Kandidát: Zuzana Rania Hrušková Školitel: Prof. RNDr. Milan Pour, PhD. Název diplomové práce: Príprava a oxidatívny coupling 1,5-disubstituovaných tetrazolov V náväznosti na predchádzajúcu prácu, ktorá viedla k príprave knižnice 1,5-disubstituovaných tetrazolov pomocou paládiom katalyzovaných cross-couplingových reakcií s priamou aktiváciou C5-H väzby, bola mojou prácou táto knižnica rozšírená o nové deriváty. 1,5-disubstituované tetrazoly boli využité ako substráty pre oxidatívny coupling. Tieto reakcie mali viesť k príprave rôznych derivátov tetrazolo[1,5-f]fenantridínu. Všetky použité metódy však viedli iba k stopám požadovaného produktu.

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/54892

Permalink: http://www.nusl.cz/ntk/nusl-324186


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses