Klinicky významné druhy kvasinek a jejich interakce s hostitelem

Novosadová, Zuzana

Pathogenic yeasts are nowadays a serious threat for mammalian host. They can cause dangerous diseases, which in many cases even result in death. Pathogens increase the chances of systemic infections by many virulence mechanisms. Experiments addressing the pathogenhost interactions are crucial for defeating these types of infections within the human body. Host-pathogen interactions are very complex and include all components of multicellular host organism. Recently, scientists have focused on the interaction of the mammalian immune system and pathogenic yeasts in more detail. This work summarises interactions of pathogen with selected host cells, especially with macrophages. Yeast pathogens, especially Candida albicans, are capable of influencing the gene expression in interacting cells. These pathogens are capable of modulating the expression while engulfed inside macrophages and other cells of the immune system. Pathogenic yeasts can also change the overall characteristics of their surrounding environment. C. albicans can sense pH and influence it. Therefore, it can increase its virulence by the changes of pH leading to autoinduction of morphological transitions. This work briefly reviews how selected yeast pathogens influence their surroundings while interacting within the host organism. Deeper...

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