Original title: The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats
Authors: Koupilová, M. ; Patočka, J. ; Barth, Tomislav
Document type: Papers
Conference/Event: Biologically Active Peptides. Conference /6./, Praha (CZ), 1999-04-21 / 1999-04-23
Year: 1999
Language: eng
Abstract: Effects of six analogs of AVP fragment 4-9 on cognitive impairment induced by cholinotoxin 3-quinuclidine benzilate (QB) or by noradrenotoxin (DSP-4) were investigated by means of Y-maze with aversive stimulation and T-maze with appetitive stimulation in Wistar rats. QB and DSP-4 induced a severe learning deficit in pretrained animals. Single preventive administration of the peptides reversed the QB and DSP-4 induced impairment of the retention of memory.
Keywords: T-maze; Y-maze
Project no.: GA306/95/0268 (CEP), CEZ:AV0Z4055905 (CEP)
Funding provider: GA ČR
Host item entry: Biologically Active Peptides

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0089374

Permalink: http://www.nusl.cz/ntk/nusl-28290


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers