Home > Conference materials > Papers > The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats
Original title:
The Effect of pyroglutamic fragments of vasopressin and oxytocin on the retention of memory after intoxication by neurotoxins QB and DSP-4 in rats
Authors:
Koupilová, M. ; Patočka, J. ; Barth, Tomislav Document type: Papers Conference/Event: Biologically Active Peptides. Conference /6./, Praha (CZ), 1999-04-21 / 1999-04-23
Year:
1999
Language:
eng Abstract:
Effects of six analogs of AVP fragment 4-9 on cognitive impairment induced by cholinotoxin 3-quinuclidine benzilate (QB) or by noradrenotoxin (DSP-4) were investigated by means of Y-maze with aversive stimulation and T-maze with appetitive stimulation in Wistar rats. QB and DSP-4 induced a severe learning deficit in pretrained animals. Single preventive administration of the peptides reversed the QB and DSP-4 induced impairment of the retention of memory.
Keywords:
T-maze; Y-maze Project no.: GA306/95/0268 (CEP), CEZ:AV0Z4055905 (CEP) Funding provider: GA ČR Host item entry: Biologically Active Peptides
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
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Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0089374