Original title: Phenotypic Analyses of the HD transgenic Minipig Model
Authors: Motlík, Jan ; Ellederová, Zdeňka
Document type: Research reports
Year: 2016
Language: eng
Abstract: The transgenic model of Huntington’s disease in minipig (TgHD) was created in 2009 and information coding the sequence of N-terminal part of human mutated huntingtin was transferred to subsequent generations from both female and male sides. In each litter, transgenic (TgHD) and wild-type (WT) piglets were born in approximately equal ratio. At present, the Laboratory of Cell Regeneration and Plasticity keeps sets of animals in F2 and F3 generations with identical genetic background and bred in identical conditions of feeding and housing. The present research project was focused on a complex of non-invasive and invasive approaches to WT and TgHD minipigs to achieve the entire phenotypic analysis of HD progression in this large animal model.
Keywords: minipig
Project no.: A-8248
Funding provider: CHDI Foundation

Institution: Institute of Animal Physiology and Genetics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0269505

Permalink: http://www.nusl.cz/ntk/nusl-263471


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Research > Institutes ASCR > Institute of Animal Physiology and Genetics
Reports > Research reports