Original title: Capillary electrophoresis with contactless conductivity detection for rapid determination of meldonium in urine
Authors: Šlampová, Andrea ; Kubáň, Pavel
Document type: Papers
Conference/Event: CECE 2016. International Interdisciplinary Meeting on Bioanalysis /13./, Brno (CZ), 20161017
Year: 2016
Language: eng
Abstract: A simple, rapid and cheap capillary electrophoresis-capacitively coupled contactless\nconductivity detection (CE-C4D) method for determination of meldonium (MEL) in\nurine samples was developed. Sample pretreatment was minimized to dilution of urine\nsamples with DI water and MEL was determined by CE-C4D in background electrolyte\nconsisting of 2 M acetic acid (pH 2.3) in ng mL−1 to mg mL−1 concentration range.\nSample-to-sample analysis time was less than 4 min, limit of detection and\nquantification was 0.015 and 0.05 μg mL−1, respectively, and the method showed\nexcellent linearity (r2 ≥ 0.9998), recovery (97.6–99.9%) and intraday as well as interday\nrepeatability (RSD ≤ 4.7%).
Keywords: capillary electrophoresis-capacitively coupled contactless conductivity detection; meldonium; urine
Project no.: GA16-09135S (CEP)
Funding provider: GA ČR
Host item entry: CECE 2016. 13th International Interdisciplinary Meeting on Bioanalysis, ISBN 978-80-904959-4-4

Institution: Institute of Analytical Chemistry AS ČR (web)
Document availability information: Fulltext is available in the digital repository of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0265921

Permalink: http://www.nusl.cz/ntk/nusl-261711


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Research > Institutes ASCR > Institute of Analytical Chemistry
Conference materials > Papers