Original title: Searching for Electrochemical Reduction Mechanism of Azidophenyl DNA Labels
Authors: Daňhel, Aleš ; Trošanová, Zuzana ; Balintová, Jana ; Hocek, Michal ; Fojta, Miroslav
Document type: Papers
Conference/Event: Moderní Elektrochemické Metody /34./, Jetřichovice (CZ), 20140519
Year: 2014
Language: eng
Abstract: This contribution brings new information to sporadic scientific results concerned to electrochemical reduction of aromatic azides. Selected compounds used as perspective DNA labels or their structural constituents such as, 4-azidophenyltrifluoroboronic acid, 4-azidophenyl modified deoxycytidine and next probable analogous compounds and/or products of their reduction, were voltammetrically studied and compared to each other in order to reveal a mechanism of their electrochemical reduction at mercury electrodes in aqueous media. Preliminary results obtained by cyclic voltammetry at mercury and carbon based electrodes and by mass spectrometry of the products isolated from batch electrolysis on mercury pool by preparative chromatography are discussed.
Keywords: aromatic azides; DNA labels; mercury electrode; reduction mechanism; voltammetry
Project no.: GBP206/12/G151 (CEP), EE2.3.30.0019
Funding provider: GA ČR, GA MŠk
Host item entry: Sborník přednášek mezinárodní odborné konference XXXIV. Moderní Elektrochemické Metody, ISBN 978-80-905221-2-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0257031

Permalink: http://www.nusl.cz/ntk/nusl-202731


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers