Original title: Chiroptical spectroscopy as a sensitive tool for the conformational analysis of antimicrobial peptides
Authors: Kocourková, L. ; Novotná, P. ; Čujová, Sabína ; Čeřovský, Václav ; Urbanová, M. ; Setnička, V.
Document type: Papers
Conference/Event: International Students Conference "Modern Analytical Chemistry" /11./, Prague (CZ), 2015-09-22 / 2015-09-23
Year: 2015
Language: eng
Abstract: We tested the utilization of electronic and vibrational circular dichroism for the conformational study of antimicrobial peptides on two examples: melectin and antapin in different solutions of liposomes and micelles mimicking bacterial or eukaryotic membranes. The results show significant content of the alpha-helical conformation in an environment mimicking the bacterial membrane, while it was considerably low in the eukaryotic membrane-mimicking environment.
Keywords: antimicrobial peptides; circular dichroism; conformation; liposomes; model membranes
Project no.: GAP208/11/0105 (CEP)
Funding provider: GA ČR
Host item entry: Proceedings of the 11th International Students Conference "Modern Analytical Chemistry", ISBN 978-80-7444-036-6

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0250628

Permalink: http://www.nusl.cz/ntk/nusl-200863


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers