Original title: Considerations on electrolysis in electromembrane extraction of basic drugs
Authors: Šlampová, Andrea ; Kubáň, Pavel ; Boček, Petr
Document type: Papers
Conference/Event: CECE 2015. International Interdisciplinary Meeting on Bioanalysis /12./, Brno (CZ), 2015-09-21 / 2015-09-23
Year: 2015
Language: eng
Abstract: Electrolysis may significantly affect composition and pH values of non-optimized acceptor solutions and have fatal consequences on quantitative EME results for weak and medium strong analytes. Acceptor solutions consisting of high concentrations of weak acids have therefore been proposed as suitable operational solutions for electromembrane extraction (EME) of selected basic drugs. 500 mM formic acid efficiently eliminated the electrolytically produced OH– ions, offered constant pH and thus long-term EME performance and was easily compatible with subsequent analytical methods. Maximum EME recoveries ranged from 66 to 89% and were constant between 40 and 80 min of EME and no back-extraction of the analytes into donor solutions was observed.
Keywords: basic drugs; electrolysis; electromembrane extraction
Project no.: GA13-05762S (CEP)
Funding provider: GA ČR
Host item entry: CECE 2015. 12th International Interdisciplinary Meeting on Bioanalysis, ISBN 978-80-904959-3-7

Institution: Institute of Analytical Chemistry AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: http://www.ce-ce.org/CECE2015/CECE%202015%20proceedings_full.pdf
Original record: http://hdl.handle.net/11104/0250466

Permalink: http://www.nusl.cz/ntk/nusl-200752


The record appears in these collections:
Research > Institutes ASCR > Institute of Analytical Chemistry
Conference materials > Papers