Název: Adenosine signaling in Drosophila
Překlad názvu: Adenosine signaling in Drosophila
Autoři: KUČEROVÁ, Lucie
Typ dokumentu: Disertační práce
Rok: 2013
Jazyk: cze
Abstrakt: This thesis characterizes adenosine signalization in Drosophila and describes response to adenosine in various cell types. Extracellular adenosine mediates most of its physiological effects through its receptors but recent data also indicate that adenosine transport also has important physiological functions. It was shown in this thesis that adenosine stimulates only cAMP second messenger system in Drosophila cells endogenously expressing AdoR. The pharmacological profile of the DmAdoR was established using the cAMP functional assay. The utility of the agonist 2-chloroadenosine and antagonist SCH58261 were examined in flies in vivo and compared with phenotypes of DmAdoR mutants. The responses of Drosophila cells to adenosine mediated by adenosine transport were also examined. Different cell types exhibited striking differences in adenosine uptake and adenosine recycling that were closely connected with the regulation of carbohydrate and lipid metabolism. This thesis provides an important foundation for the study of interactions between adenosine receptor and adenosine transport.
Klíčová slova: adenosine recycling; AdoR; ATP synthesis; calcium; CG5793; cyclic AMP; GloSensor; GPCR; nucleoside transport; adenosine recycling; AdoR; ATP synthesis; calcium; CG5793; cyclic AMP; GloSensor; GPCR; nucleoside transport
Citace: KUČEROVÁ, Lucie. Adenosine signaling in Drosophila. České Budějovice, 2013. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Instituce: Jihočeská univerzita v Českých Budějovicích (web)
Informace o dostupnosti dokumentu: Plný text je dostupný v digitálním repozitáři JČU.
Původní záznam: http://www.jcu.cz/vskp/6164

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-151838


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Jihočeská univerzita v Českých Budějovicích
Vysokoškolské kvalifikační práce > Disertační práce