|
|
Diabetes mellitus type II in the light of metabolic syndrome
Hrnčířová, Eliška ; Rudolf, Kamil (advisor) ; Doseděl, Martin (referee)
DIABETES MELLITUS TYPE II IN THE LIGHT OF METABOLIC SYNDROME Author: Eliška Hrnčířová ¹ Tutor: MUDr. PharmDr. Kamil Rudolf, Ph.D. ¹, š ¹ Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové š II. intern gastroenterology clinic University Hospital Hradec Králové Background: My thesis deals with diabetes mellitus, a common chronic civilization disease, the essence of its creation, including the issue of the treatment, regime measures and it also mentions the associated health problems connected to the diagnosis. The Aim of the study: The main purpose of this work based on a small sample of patients was to verify their level of information and knowledge of the disease, compliance, participation in home blood glucose measurements and to determine the health complications associated with diabetes and its treatment. Methods: The study was carried out by questionnaire in a paper form. Data were obtained in a pharmacy during a short interview with 209 randomly selected diabetics type II. The questionnaire included two main characteristics of respondents (gender, age) and 6 simple targeted questions. Results: In the survey 59 % female and 41% male took part. The mean age of patients was 66.9 years. Respondents were diagnosed with DM on average 11.1...
|
|
|
Analysis of prescription and potential drug interactions in patients with inflammatory bowel disease.
Antoušková, Helena ; Vlček, Jiří (advisor) ; Rudolf, Kamil (referee)
Background: Concurrent use of multiple drugs often increases therapeutic effectiveness, but very often may also pose a risk for drug interactions. These may result in severe clinical manifestation, if they are not paid an attention and unproperly managed. Aim: To assess percentage of potential drug interactions in the population of patients with diagnosis of inflammatory bowel disease (IBD) and suggest their management. Methods: 177 patients with IBD (84 male, 93 female, mean age 36,9, range 16 - 78, 117 CD, 60 UC) enrolled. Their complete medication was gained by means of an interview and subsequently evaluated and processed with Thomson MICROMEDEX® DRUG - REAX® System to reveal potential drug interactions. All the identified drug interactions were taken as potential. There was no prove if patient was harmed by them. Results: In CD, the most prescribed drugs were aminosalicylates (39 %), corticosteroids (both topical and systemic)(21 %) and immunosupressants (23 %). The other prescribed medicines were proton pump inhibitors, iron containing preparates, probiotics and TNF-α inhibitors. In UC, the most prescribed drugs were aminosalicylates (51 %), corticosteroids (both topical and systemic)(22 %) and immunosupressants again (13 %). The other prescribed medicines were proton pump inhibitors, iron...
|
|
|
Arterial hypertension - patients point of view in the public pharmacy
Jonášová, Iveta ; Rudolf, Kamil (advisor) ; Malý, Josef (referee)
Arterial hypertension - patients point of view in the public pharmacy Author: Iveta Jonášová ¹ Tutor: MUDr. PharmDr. Kamil Rudolf, Ph.D. ¹ š ¹ Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové š University Hospital Hradec Králové Background: The thesis deals with pharmacotherapy of arterial hypertension. Arterial hypertension is one from the most common diseases of the cardiovascular system. Current therapy and control over arterial hypertension are not sufficient, despite of progress in pharmacotherapy and introduction of new antihypertensive drugs into medication. Aim of study: Aim of this study was to find a deeper knowledge of hypertonic patients about their disease, their compliance with therapy and doctor's instructions and pacient's knowledge about their actual blood pressure. Effect of antihypertensive therapy was assessed including conformity local prescribing with current guidelines. Methods: Data of the prospective study were collected by a questionnaire. The exploratory sample was consisted of randomly 320 surveyed hypertensive patients living in the Štětí and its surroundings. The research was performed from July 2010 to November 2011. The questionnaire consisted of two respondent characteristics (sex, age) and 7 targeted...
|
|
|
Analysis of drug related problems identificated by pharmacist during provision dispensation and the influence of pharmacist's intervention on prescribing doctors
Močárková, Zdeňka ; Vlček, Jiří (advisor) ; Rudolf, Kamil (referee)
Analysis of drug related problems identificated by pharmacist during provision dispensation and the influence of pharmacist's intervention on prescribing doctors Author: Mgr. Zdeňka Močárková 1 Consultant: Prof. RNDr. Jiří Vlček, CSc. 2 1 Community pharmacy in Chrastava 2 Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Introduction: Drug problems (drug related problems, DRPs) shall mean all the circumstances involving drug therapy that can actually or potentially interfere with the expected outcome of therapeutic intervention. The solution DRPs (risk of pharmacotherapy) includes their detection, risk assessment and selection of the appropriate intervention and belongs to the one of the fundamental activities of a pharmacist. Aim of study: The aim of this work was to analyze DRPs, their use as a tool for discussion with doctors and subsequent evaluation and estimation of the limits of this model of cooperation between doctor and pharmacist. Methods: A prospective observational study was conducted in the village Chrastava (1 public pharmacy). Record DRPs detected pharmacist during provision dispensation was conducted in two equally long periods (2 x 30 working days) by using electronic databases (including data of patient, patient used...
|
|
|
Pharmaceutical care of Obese Patients
Dobrucká, Katarína ; Vlček, Jiří (advisor) ; Rudolf, Kamil (referee)
PHARMACEUTICAL CARE OF OBESE PATIENTS Author: Dobrucká K. * Tutor: Vlček J. ** * Department of clinical pharmacy, Na Homolce Hospital, Prague, Czech Republic ** Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Obesity is a chronic disease associated with increased morbidity and mortality. Contact with the obese patient is a daily practice for pharmacists and pharmacy is often the first point of capture of risk patient in terms of developing health problems associated with obesity. The role of the pharmacist is providing pharmaceutical care to patients with obesity in the pharmacy and its involvement in the health care team in management of obesity. Aim of study: The work points out to the possible intervention of pharmacists and FA in securing the safety of self-medication in dispensing drugs OTC orlistat and in individual consultations for weight reduction in pharmacy. Method: The study worked with two groups of patients who visited ÚL IKEM for self- treatment with orlistat in the period June-December 2009 and consultations for weight reduction in the period May 2006 - May 2010. The data were collected by pharmacists and PA through anonymous questionnaires for dispensing OTC orlistat and by pharmacists...
|
|
|
Diabetes mellitus type II in the light of metabolic syndrome
Hrnčířová, Eliška ; Rudolf, Kamil (advisor) ; Doseděl, Martin (referee)
DIABETES MELLITUS TYPE II IN THE LIGHT OF METABOLIC SYNDROME Author: Eliška Hrnčířová ¹ Tutor: MUDr. PharmDr. Kamil Rudolf, Ph.D. ¹, š ¹ Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové š II. intern gastroenterology clinic University Hospital Hradec Králové Background: My thesis deals with diabetes mellitus, a common chronic civilization disease, the essence of its creation, including the issue of the treatment, regime measures and it also mentions the associated health problems connected to the diagnosis. The Aim of the study: The main purpose of this work based on a small sample of patients was to verify their level of information and knowledge of the disease, compliance, participation in home blood glucose measurements and to determine the health complications associated with diabetes and its treatment. Methods: The study was carried out by questionnaire in a paper form. Data were obtained in a pharmacy during a short interview with 209 randomly selected diabetics type II. The questionnaire included two main characteristics of respondents (gender, age) and 6 simple targeted questions. Results: In the survey 59 % female and 41% male took part. The mean age of patients was 66.9 years. Respondents were diagnosed with DM on average 11.1...
|
|
|
Analysis of drug related problems identificated by pharmacist during provision dispensation and the influence of pharmacist's intervention on prescribing doctors
Močárková, Zdeňka ; Vlček, Jiří (advisor) ; Rudolf, Kamil (referee)
Analysis of drug related problems identificated by pharmacist during provision dispensation and the influence of pharmacist's intervention on prescribing doctors Author: Mgr. Zdeňka Močárková 1 Consultant: Prof. RNDr. Jiří Vlček, CSc. 2 1 Community pharmacy in Chrastava 2 Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Introduction: Drug problems (drug related problems, DRPs) shall mean all the circumstances involving drug therapy that can actually or potentially interfere with the expected outcome of therapeutic intervention. The solution DRPs (risk of pharmacotherapy) includes their detection, risk assessment and selection of the appropriate intervention and belongs to the one of the fundamental activities of a pharmacist. Aim of study: The aim of this work was to analyze DRPs, their use as a tool for discussion with doctors and subsequent evaluation and estimation of the limits of this model of cooperation between doctor and pharmacist. Methods: A prospective observational study was conducted in the village Chrastava (1 public pharmacy). Record DRPs detected pharmacist during provision dispensation was conducted in two equally long periods (2 x 30 working days) by using electronic databases (including data of patient, patient used...
|
|
|
Arterial hypertension - patients point of view in the public pharmacy
Jonášová, Iveta ; Rudolf, Kamil (advisor) ; Malý, Josef (referee)
Arterial hypertension - patients point of view in the public pharmacy Author: Iveta Jonášová ¹ Tutor: MUDr. PharmDr. Kamil Rudolf, Ph.D. ¹ š ¹ Department of Clinical and Social Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové š University Hospital Hradec Králové Background: The thesis deals with pharmacotherapy of arterial hypertension. Arterial hypertension is one from the most common diseases of the cardiovascular system. Current therapy and control over arterial hypertension are not sufficient, despite of progress in pharmacotherapy and introduction of new antihypertensive drugs into medication. Aim of study: Aim of this study was to find a deeper knowledge of hypertonic patients about their disease, their compliance with therapy and doctor's instructions and pacient's knowledge about their actual blood pressure. Effect of antihypertensive therapy was assessed including conformity local prescribing with current guidelines. Methods: Data of the prospective study were collected by a questionnaire. The exploratory sample was consisted of randomly 320 surveyed hypertensive patients living in the Štětí and its surroundings. The research was performed from July 2010 to November 2011. The questionnaire consisted of two respondent characteristics (sex, age) and 7 targeted...
|
|
|
The mechanism of cell death induction in human malignant melanoma in vitro
Rudolf, Kamil ; Červinka, Miroslav (advisor) ; Mlejnek, Petr (referee) ; Janisch, Roman (referee)
Melanoma is a complex malignant disease characterized by increasing incidence and mortality. Melanoma biology is complicated and comprises many aberrant genes and signaling pathways. Treatment of melanoma relies on surgery, the role of radiation therapy and chemotherapy are limited. In advanced disseminating and metastasizing melanoma chemotherapy largely fails and that is why new approaches are being sought including identification of deregulated molecules or processes which could be used as targets. Some of these targets center on frequently aberrant cell death regulating mechanisms. Some traditional cytostatic drugs such as inhibitors of topoisomerases although useful in other types tumors so far proved useless in treatment of melanoma. Nevertheless, expression of topoisomerases in melanoma is often high, thereby enabling at least theoretically their use as targets for chemotherapeutical intervention. Aim of this study was to assess the cytoxicity and proapoptotic effect of campthotecin (topoisomerase I inhibitor), etoposide (topoisomerase IIα inhibitor) and their combination in selected human melanoma cell lines. We found that campthotecin may induce apoptosis by a combination of mechanisms including p53 as well as p73 and kaspase-2. Etoposide-induced cell death in Bowes melanoma cells included...
|
|
|
Analysis of prescription and potential drug interactions in patients with inflammatory bowel disease.
Antoušková, Helena ; Vlček, Jiří (advisor) ; Rudolf, Kamil (referee)
Background: Concurrent use of multiple drugs often increases therapeutic effectiveness, but very often may also pose a risk for drug interactions. These may result in severe clinical manifestation, if they are not paid an attention and unproperly managed. Aim: To assess percentage of potential drug interactions in the population of patients with diagnosis of inflammatory bowel disease (IBD) and suggest their management. Methods: 177 patients with IBD (84 male, 93 female, mean age 36,9, range 16 - 78, 117 CD, 60 UC) enrolled. Their complete medication was gained by means of an interview and subsequently evaluated and processed with Thomson MICROMEDEX® DRUG - REAX® System to reveal potential drug interactions. All the identified drug interactions were taken as potential. There was no prove if patient was harmed by them. Results: In CD, the most prescribed drugs were aminosalicylates (39 %), corticosteroids (both topical and systemic)(21 %) and immunosupressants (23 %). The other prescribed medicines were proton pump inhibitors, iron containing preparates, probiotics and TNF-α inhibitors. In UC, the most prescribed drugs were aminosalicylates (51 %), corticosteroids (both topical and systemic)(22 %) and immunosupressants again (13 %). The other prescribed medicines were proton pump inhibitors, iron...
|
guest ::
