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Poland as a new regional power
Parolek, Jan ; Kučera, Tomáš (advisor) ; Kofroň, Jan (referee)
This work concerns the question whether it is possible to consider Poland a new regional power in the Central and/or Eastern Europe. The work is based on constructivist viewpoint and it therefore examines the self-perception of Poland and the perception of its role by other relevant actor. It establishes a definition of a regional power, by which a regional power is a state that considers itself to be such power, that is considered to be such power by other relevant actors, that provides public goods in its region and the projects its ideology onto the secondary regional actors. I examine how well does Poland fit into these criteria. It surely considers itself a regional power and is even considered one by its western allies. Its actual acting as a regional power is complicated, though by its insufficient economic power (in comparison with, for example, Germany) as it does not allow him an effective provision of public goods. Also its regional ideology is not sufficiently coherent and inclusive and interesting for the other actors. Besides all that, it is faced by a Russian competition in the Eastern Europe and by the indifference of the potential secondary actors in the Central Europe, as they tend to orientate themselves to Germany, rather than Poland. Poland undeniably has the potential to...
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Poland as a new regional power
Parolek, Jan ; Kučera, Tomáš (advisor) ; Kofroň, Jan (referee)
This work concerns the question whether it is possible to consider Poland a new regional power in the Central and/or Eastern Europe. The work is based on constructivist viewpoint and it therefore examines the self-perception of Poland and the perception of its role by other relevant actors. It establishes a definition of a regional power, by which a regional power is a state that considers itself to be such power, that is considered to be such power by other relevant actors, that provides public goods in its region and the projects its ideology onto the secondary regional actors. I examine how well does Poland fit into these criteria. It surely considers itself a regional power and is even considered one by its western allies. Its actual acting as a regional power is complicated, though, by its insufficient economic power (in comparison with, for example, Germany) as it does not allow him an effective provision of public goods. Also its regional ideology is not sufficiently coherent and inclusive and interesting for the other actors. Besides all that, it is faced by a Russian competition in the Eastern Europe and by the indifference of the potential secondary actors in the Central Europe, as they tend to orientate themselves to Germany, rather than Poland. Poland undeniably has the potential to...
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The causes of terrorist radicalisation among Northern Irish Catholics
Parolek, Jan ; Aslan, Emil (advisor) ; Charvát, Jan (referee)
This work deals with the question of whether, in the case of terrorist radicalization of Northern Irish Catholics (being both national and a religious minority in the Northern Ireland and de facto also in the UK) during 'The Troubles', was ideology only a function of Catholics' socio-economic grievances, or a standalone, individually decisive factor. The thesis explores the motivations for terrorism as they are stated in personal testimonies, group surveys, or other sources. The theory of Radicalization Puzzle, viewing the radicalization as a complex non-linear combination of four variously strong categories of reasons (grievances, ideologies, networks and support structures) is used. After establishing the definitions of terrorism and minority status, exploring the Irish-British history and the validity of minority status of Northern Irish Catholics, the paper brings together the stated reasons for radicalisation and combines them in a "mental map." Several broad categories of reasons are identified and overlaid with the Puzzle categories. It is found that grievances were a big motivational factor for terrorism, but they were overwhelmingly of social kind, mostly sectarian or state violence. Economic grievances as a dominant radicalising factor were very rare. The Republican ideology has also been a...
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Magazine Dikobraz 1968 - 1970
Parolek, Jan ; Slanec, Jaroslav (advisor) ; Osvaldová, Barbora (referee)
This work concerns the question whether it is possible to consider Poland a new regional power in the Central and/or Eastern Europe. The work is based on constructivist viewpoint and it therefore examines the self-perception of Poland and the perception of its role by other relevant actor. It establishes a definition of a regional power, by which a regional power is a state that considers itself to be such power, that is considered to be such power by other relevant actors, that provides public goods in its region and the projects its ideology onto the secondary regional actors. I examine how well does Poland fit into these criteria. It surely considers itself a regional power and is even considered one by its western allies. Its actual acting as a regional power is complicated, though by its insufficient economic power (in comparison with, for example, Germany) as it does not allow him an effective provision of public goods. Also its regional ideology is not sufficiently coherent and inclusive and interesting for the other actors. Besides all that, it is faced by a Russian competition in the Eastern Europe and by the indifference of the potential secondary actors in the Central Europe, as they tend to orientate themselves to Germany, rather than Poland. Poland undeniably has the potential to...
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Poland as a new regional power
Parolek, Jan ; Kučera, Tomáš (advisor) ; Kofroň, Jan (referee)
This work concerns the question whether it is possible to consider Poland a new regional power in the Central and/or Eastern Europe. The work is based on constructivist viewpoint and it therefore examines the self-perception of Poland and the perception of its role by other relevant actor. It establishes a definition of a regional power, by which a regional power is a state that considers itself to be such power, that is considered to be such power by other relevant actors, that provides public goods in its region and the projects its ideology onto the secondary regional actors. I examine how well does Poland fit into these criteria. It surely considers itself a regional power and is even considered one by its western allies. Its actual acting as a regional power is complicated, though by its insufficient economic power (in comparison with, for example, Germany) as it does not allow him an effective provision of public goods. Also its regional ideology is not sufficiently coherent and inclusive and interesting for the other actors. Besides all that, it is faced by a Russian competition in the Eastern Europe and by the indifference of the potential secondary actors in the Central Europe, as they tend to orientate themselves to Germany, rather than Poland. Poland undeniably has the potential to...
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Poland as a new regional power
Parolek, Jan ; Kučera, Tomáš (advisor) ; Kofroň, Jan (referee)
This work concerns the question whether it is possible to consider Poland a new regional power in the Central and/or Eastern Europe. The work is based on constructivist viewpoint and it therefore examines the self-perception of Poland and the perception of its role by other relevant actors. It establishes a definition of a regional power, by which a regional power is a state that considers itself to be such power, that is considered to be such power by other relevant actors, that provides public goods in its region and the projects its ideology onto the secondary regional actors. I examine how well does Poland fit into these criteria. It surely considers itself a regional power and is even considered one by its western allies. Its actual acting as a regional power is complicated, though, by its insufficient economic power (in comparison with, for example, Germany) as it does not allow him an effective provision of public goods. Also its regional ideology is not sufficiently coherent and inclusive and interesting for the other actors. Besides all that, it is faced by a Russian competition in the Eastern Europe and by the indifference of the potential secondary actors in the Central Europe, as they tend to orientate themselves to Germany, rather than Poland. Poland undeniably has the potential to...
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Evaluation of the properties of polymer conjugates which specifically bind proteins and can be used in molecular biology
Parolek, Jan ; Konvalinka, Jan (advisor) ; Liberda, Jiří (referee)
During last three decades, a great effort was invested to the development of polymer conjugates of low molecular drugs with the aim to improve the specific targeting of drugs to diseased tissues, cells and organs. The main reason for this effort was the fact that high molecular weight copolymers have a favourite distribution profile in tissues and organisms. A linker between a polymer backbone and drug has very important role: it is possible to synthesize a biodegradable linker, which can be enzymatically hydrolyzed. Conversely, there is a possibility to synthesize an inert linker, resistant to the hydrolysis. Proper choice of the suitable precursor- polymer is also essential, hence it has to accomplish all of the stringent demands for biocompatibility. Macromolecular polymer-drug conjugates tend to accumulate in solid tumors because of the so called enhanced permeability and retention (EPR) effect. There is a whole range of possible applications of high molecular polymer-drug conjugates. In the introduction part of this thesis, I summarize potential use of drugs based on poly(N-(2-hydroxypropyl)methacrylamide) (HPMA) copolymers. Moreover, I introduce some therapeutically important proteins used in experimental drug discovery. In our laboratory, we have developed a concept of HPMA copolymers...
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Preparation of affinity resin for the identification and preparation of glutamate carboxypeptidase II in biological material
Parolek, Jan ; Konvalinka, Jan (advisor) ; Bořek Dohalská, Lucie (referee)
For treatment of benign and malignant tumors it is desirable to find more specific and less burdening ways of therapy. The main objective of improving the treatment of inoperable tumors is as low as possible damage to healthy tissues during tumor tissue elimination. Using antibodies in research and therapy brought significant progress; antibodies are able not to only mark cells expressing certain molecules, but even to eliminate them. However, tumor cells are very similar to healthy cells and this similarity is one of the major problems in treatment of cancer; most of the substances toxic to tumor have also some adverse effect on the whole organism. For this reason, it is necessary to search new tumor-specific markers for treatment of tumor-based diseases. Monoclonal antibodies can be linked with a drug molecule (cytotoxic substance, radionuclide, etc.) and getting antibody- drug conjugate. These conjugates are very promising medicaments for carcinoma treatment because monoclonal antibody can find specific target and drug substance can be delivered locally with minimal harm to patient's organism. Glutamate carboxypeptidase II (GCPII) became one of the specific markers for the prostate cancer. GCPII is an integral membrane protein, which is highly expressed by epithelial cells of the prostate...
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