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National Repository of Grey Literature

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	C Substitution in position 7 of pyrrolo [3,2- d] pyrimidines by cross-coupling reactions Bambuch, Vítězslav ; Otmar, Miroslav (advisor) ; Dvořák, Dalimil (referee) Detailed record
	Nucleosides containing 8-aza-7,9-dedeazaxanthine Mařák, David ; Otmar, Miroslav ; Dračínský, Martin ; Krečmerová, Marcela 8-aza-7,9-dideazaxanthine nucleosides were prepared from 5-nitrouracil employing a Barton-Zard reaction. Detailed record
	Chemical synthesis of prodrugs derived from 5,6-dihydro-5-azacytosine and its nucleosides using vinyl esters Janská, Lucie ; Blažek, Jiří ; Mařák, David ; Otmar, Miroslav ; Krečmerová, Marcela New strategy for synthesis of amide prodrugs without protecting groups for 5,6-dihydro-5-azacytosine and its nucleosides was developed and introduced. Vinyl esters were used as acyl donor and the reactive amino group on the heterocycle functions as nucleophile. Detailed record
	Nukleosidy a nukleotidy obsahující 8-aza-7,9-dideazaxanthin Mařák, David ; Otmar, Miroslav ; Dračínský, Martin ; Votruba, Ivan ; Holý, Antonín The described preparation of 8-aza-7,9-dideazaxanthine from 1,3-dibenzyluracil and TosMIC was improved by using AlCl3 for final debenzylation. Treatment of 6-dibromomethyl- 5-formyluracil with benzyl-, 4-methoxybenzyl-, and 1-adamantylamine gave the corresponding 8-alkyl-8-aza-7,9-dideazaxanthines. N1- and N8-(8-phosphonooctyl)-8-aza-7,9-dideazaxanthines were prepared and found as inhibitors of thymidine phosphorylase (V79 cells, human placenta, Escherichia coli). IC50 values ranged at 3–27 .mu.M. Detailed record
	Acyklické nukleosidfosfonáty obsahující O-substituované hydroxypyridinaminy a diaminy jako nukleobase Otmar, Miroslav ; Masojídková, Milena ; Holý, Antonín Congeners of the PMEO class of acyclic nucleoside phosphonates containing pyridine instead of pyrimidine ring were synthesized. Detailed record
	Synthesis and cytostatic activity of 2,6-diamino-9-benzyl-9-deazapurine and related compounds Otmar, Miroslav ; Masojídková, Milena ; Votruba, Ivan ; Holý, Antonín 2,6-Diamino-9-benzyl-9-deazapurine and 9-benzyl-2,6-bis(benzylamino)-9-deazapurine were synthesized by reductive cyclization of the corresponding 6-cyanomethyl-5-nitropyrimidines. Both compounds exhibit cytostatic activity in human T-lymphoblastoid CCRF-CEM cells. Detailed record
	An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives Otmar, Miroslav ; Votruba, Ivan ; Holý, Antonín Detailed record
	Synthesis of .I.N./I..sup.4./sup.-alkyl-5-azacytidines and their base pairing with carbamoylguanidines - a contribution to explanation of the mutagenicity of 5-aza-2'-deoxycytidine Pískala, Alois ; Hanna, N. ; Masojídková, Milena ; Otmar, Miroslav ; Fiedler, Pavel Detailed record
	Synthesis of acyclic 9-deazanucleosides: 9-(2,3-dihydroxypropyl)-9-deazahypoxanthine Otmar, Miroslav ; Masojídková, Milena ; Holý, Antonín Detailed record
	Structural Features of Acyclic Nucleotide Analogs Conferring Inhibitory Effects on Cellular Replicative DNA Polymerases Kramata, Pavel ; Birkuš, Gabriel ; Otmar, Miroslav ; Votruba, Ivan ; Holý, Antonín Detailed record

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