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Family house with the establishment
Jelínková, Lenka ; Žajdlík, Tomáš (referee) ; Šuhajdová, Eva (advisor)
This bachelor thesis deals with the design and elaboration of project documentation for the construction of a family house with the establishment in Bystřice pod Hostýnem. The building is designed for housing a family of five and the operation of the car repair workshop. The house has a garage. The living area has two floors and with partial basement. The establishment consists of one above-ground floor. The building is designed from Silka limestone blocks. The external wall of the basement consists of concrete blocks. The ceilings are from the Ytong system. The roofing consists of a gabled roof with a dormer, above the establishment is a flat green roof. The building has ventilated facade and hidden downpipe.
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Hotel
Jelínková, Lenka ; Spáčil, Miroslav (referee) ; Sukopová, Dáša (advisor)
The subject of diploma thesis is the design of a hotel in the cadastral area of Kozlovice u Přerova. The building is designed for short term accommodation. The building has three floors and with partial basement. The hotel has the wellness zone in basement and the restaurant on the first floor. On the second and thirt floor there are rooms for guests. Before the hotel is a parking. From the construction point of wiev the building is designed as an object made of clay brick with reinforced concrete floor. The building has warm flat roof. The hotel is insulated with mineral wool. The building has ventilated facade.
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Analýza užitkových vlastností chovu prasat zařazeného do kontroly užitkovosti
JELÍNKOVÁ, Lenka
The aim of the diploma thesis was to analyse reproductive and productive parameters at a particular pig farm participating in the performance testing. The monitoring took place between years 2019 to 2021. The sow reproductive traits included sows of the Czech Large White - CLW (977 litters), CLW x CL (CL = Czech Landrace) (616 litters), Duroc (169 litters), Pietrain (156 litters), 125 litters by boars D x LWSL (Large White - sire line) and 146 litters by boars Pn x LWSL. Higher number of total born (15.6 vs. 15.4 pcs), live-born (14.5 vs. 14.3 pcs) and weaned piglets (13.5 vs. 13.2 pcs) was confirmed within maternal breeds in CLW x CL sows, compared to CLW sows. The highest number of total born, live-born and weaned piglets was confirmed within the paternal breeds after boars D x LWSL (11.2 pcs, 10.3 pcs and 9.6 pcs). The lowest fertility level was found out at the Pietrain breed (10.0 total born, 9.2 live-born and 7.7 weaned piglets). Boars of the CLW (1,448 pcs), Duroc (434 pcs), Pietrain (339 pcs), D x LWOL (368 pcs) and BO x Pn (363 pcs) and gilts of the CLW (3,479 pcs), Duroc (487 pcs) and Pietrain (343 pcs) were analysed in field test. The highest average daily gain from the birth was achieved by boars LWSL x Pn (730 g), the lowest average backfat thickness was achieved by boars D x LWSL (5.2 mm) and the highest lean meat content was achieved by boars Pietrain (62.2%). The best performance traits in the field test were recorded in boars in 2020. The highest value of the average daily gain from the birth was in CLW gilts(659 g) and the lowest average backfat thickness (5.2 mm) and the highest lean meat content (62.5%) were in Pn gilts. The best results of the field test of gilts were reached in 2021.
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Sexuální projevy u kanců a prasnic
JELÍNKOVÁ, Lenka
The bachelor thesis deals with sexual manifestations in boars and sows. The aim of this thesis is to monitor and evaluate sexual manifestations in boars and sows in conventional breeding. The bachelor thesis is divided into a theoretical and a practical part. The theoretical part is focused on the importance of breeding, breeding history, pig numbers and the breeding system in the Czech Republic. The focus is then placed on the development of pig genitals, sexual activity management, sexual behavior and sexual reflexes. The practical part covers the principal assessment, which is based on permanent monitoring of pigs during sexual intercourse. Individual sexual reflexes time duration, specific manifestations or caregiver interventions are closely followed. Sexual behavior was monitored in a pig herd numbering 17 boars and 71 sows (of which 10 were gilts) with a total number of 202 matings, of which 102 were successful (need for assistance being 51.8 %) and 100 unsuccessful. The results were formulated in tables and graphs.
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The role of innate immunity cells in the pathogenesis of celiac disease
Dáňová, Klára ; Palová Jelínková, Lenka (advisor) ; Černý, Jan (referee)
Celiac disease is an autoimmune disease which occurs in susceptible individuals after ingestion of food containing gluten. Gluten and its monomeric fraction gliadin induce inflammatory damage of the small intestine by activating the immune cells that react strongly to gluten peptides. Gluten peptides have the ability to activate cells of adaptive as well as innate immune system. This work is focused on the production of interleukin (IL)-1 in antigen presenting cells stimulated with peptic gliadin digest. We found that monocytes and peripheral blood mononuclear cells (PBMC) isolated from blood of celiac patients secrete significantly more IL-1α and IL-1β than cells of healthy donors after stimulation with gliadin digest. The gliadin-induced IL-1β expression is controlled by a signaling cascade that includes MAPK kinase family molecules and transcription factor NF-κB. Moreover, we found that the adaptor proteins MyD88 and TRIF as well as Toll-like receptor (TLR) 2 and 4 play a role in the signaling cascade underlying gliadin-induced IL-1β expression by using murine bone marrow derived dendritic cells (BMDC). The precursor form of IL-1β in gliadin- stimulated PBMC and murine BMDC is maturated by caspase-1. In celiac PBMC the gliadin- induced maturation and secretion of IL-1β depends on the potassium...
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Hotel
Jelínková, Lenka ; Spáčil, Miroslav (referee) ; Sukopová, Dáša (advisor)
The subject of diploma thesis is the design of a hotel in the cadastral area of Kozlovice u Přerova. The building is designed for short term accommodation. The building has three floors and with partial basement. The hotel has the wellness zone in basement and the restaurant on the first floor. On the second and thirt floor there are rooms for guests. Before the hotel is a parking. From the construction point of wiev the building is designed as an object made of clay brick with reinforced concrete floor. The building has warm flat roof. The hotel is insulated with mineral wool. The building has ventilated facade.
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Family house with the establishment
Jelínková, Lenka ; Žajdlík, Tomáš (referee) ; Šuhajdová, Eva (advisor)
This bachelor thesis deals with the design and elaboration of project documentation for the construction of a family house with the establishment in Bystřice pod Hostýnem. The building is designed for housing a family of five and the operation of the car repair workshop. The house has a garage. The living area has two floors and with partial basement. The establishment consists of one above-ground floor. The building is designed from Silka limestone blocks. The external wall of the basement consists of concrete blocks. The ceilings are from the Ytong system. The roofing consists of a gabled roof with a dormer, above the establishment is a flat green roof. The building has ventilated facade and hidden downpipe.
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The role of the immune system in the immunopathogenesis of autoimmune diseases and the therapeutic modulation of autoimmune reaction by tolerogenic dendritic cells
Dáňová, Klára ; Palová Jelínková, Lenka (advisor) ; Prokešová, Ludmila (referee) ; Heneberg, Petr (referee)
Immunotherapy based on dendritic cells (DCs) was first tested in clinical trials for the treatment of cancer in the 1990s. Currently, the ability of DCs to modulate immune responses is also being tested in several clinical studies focusing on autoimmune disease treatment with the aim of suppressing the overactivated immune system and restoring immune tolerance. For this purpose, so-called tolerogenic DCs with considerable suppressive potential are used. Tolerogenic DCs can be generated ex vivo from monocytes using pharmacological agents, which in DCs induce a regulatory phenotype with low expression of activation markers, high expression of inhibitory markers and secretion of suppressive cytokines. In the first part of this study, we show that cultivation of human blood monocytes in the presence of glucocorticoid dexamethasone and 19- nor-1,25-dihydroxyvitamin D2 (paricalcitol) enables ex vivo generation of tolerogenic DCs with a highly stable suppressive phenotype characterized by upregulated IL-10 production, inhibitory IL- T3 and PD-L1 molecule expression, the low stimulatory capacity and the ability to induce regulatory T cell development. Moreover, we show that metabolic changes and signaling through NF-κB, p38 MAPK, ERK1/2 molecules and the mTOR/STAT3 pathway play an important role in the...
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Liturgical Music as Curriculum in Primary School
Jelínková, Lenka ; Stříteská, Leona (advisor) ; Bělohlávková, Petra (referee)
Title: Liturgical Music as Curriculum in Primary School Author: Bc. Lenka Jelínková Supervisor: PhDr. Leona Saláková, Ph.D. Department: Department of Music Education, Charles University in Prague Abstract: This thesis speaks about the liturgical music taught in Czech primary schools. Firstly, the meaning of liturgical music is explained, we focus at the liturgy and its forms, then we present the survey results about teaching liturgical music, thirdly the textbooks are analyzed - we look for liturgical music as curriculum here, and in the end, there is our owns project for teaching the liturgical music. Project is about the Passion. The main goal of this work is to chart how is liturgical music in textbooks and at school approached and to give some ideas for working with liturgical music during music lessons in primary schools. Keywords: liturgy, liturgical music, music textbooks, liturgical music in primary school, spiritual music in primary school
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The innate immunity and circulating monocytes - their significance and function in pathogenesis of coeliac disease.
Němečková, Iva ; Daňková, Pavlína (advisor) ; Palová Jelínková, Lenka (referee)
8 Abstract Introduction: Celiac disease is indentified as the loss of oral tolerance to gluten, it is an organ-specific autoimmune disease in which both, adaptive and innate immunity participate. Monocytes are important part of immune system; they have many functions and express very diverse membrane receptors including Toll-like receptors (TLRs). TLRs are involved in the innate immune response, specifically TLR2 and TLR4 are crucial for recognition of bacterial components and TLR7 recognizes virus's ssRNA. Monocytes also produce prolaktin (PRL), which acts as a cytokine that modulates immune responses. To clarify the role of innate immunity and circulating monocytes in pathogenesis of celiac disease, we focused on changes in expression of selected Toll-like receptors (TLR2, TLR4, TLR7), prolactin, some pro- a anti-inflammatory cytokines (TNF-α, IL-6, IL-12, IL-10). We monitored the influence of the SNP - 1149 G/T on the expression of PRL mRNA. Another objective of this work was the introduction and optimization of in vitro methods for cultivation and stimulation of peripheral monocytes. Material and Methods: This pilot study includes 21 patients with celiac disease and 40 healthy controls. For determination of mRNA levels of the studied genes we isolated RNA from monocytes that were isolated by...
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