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Tokové vlastnosti tekutých vaječných hmot
Doležal, Martin
This diploma thesis deals with selected rheological properties of egg yolks, proteins and mélange in hen eggs, eggs enriched with vitamin D and eggs enriched with Selenium and Iodine. The eggs were stored for 4 weeks at a constant temperature of 6 ° C. Furthermore, the work describes the effect of storage on the physical properties (weight and shape index) of eggs. Eggs lost weight during four weeks of storage. The paper also described the effect of storage on the properties of egg white and yolk - for protein the index of protein and Haugh's unit and for yolk the color, yolk index and weight. There was significant change in yolk weight during storage. The yolk index gradually decreased during storage. The protein index and Haugh units decreased during storage for the first two weeks and there was a slight increase in the fourth week. Finally, the rheological properties of liquid egg masses in the given samples of hen's eggs were determined, namely density, apparent viscosity and shear stress depending on the shear rate (flow curves). The storage time affected the flow properties of the egg masses in all eggs, and the diet of the laying hens also affected properties of the eggs. Rheological behavior was modeled using the Ostwald-de Waele (power law) model.
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Relationship between Structure and Biological Activity of new Modulators of Acetylcholinesterase
Komlóová, Markéta ; Doležal, Martin (advisor) ; Kuneš, Jiří (referee) ; Jampílek, Josef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Dpt. of Pharmaceutical Chemistry and Drug Control Student: Mgr. Markéta Komlóová Supervisor: prof. PharmDr. Martin Doležal, Ph.D. Title of Doctoral Thesis: Relationship between structure and biological activity of new modulators of acetylcholinesterase This work focuses on the preparation of peripherally acting AChE inhibitors as a potential treatment of myasthenia gravis. These compounds could also be used as a pre- treatment of poisoning by organophosphorus AChE inhibitors. They can occupy the active site of an enzyme making it inaccessible for irreversible inhibitors. Compounds used in this indication should fulfill these requirements: inhibit efficiently AChE (standards currently used in the treatment were chosen for the comparison of the inhibitory efficacy), have selective effect on AChE and not to cross the blood-brain barrier in order to lower the possible side effects. Six series of bisquaternary compounds were prepared. Their inhibitory ability was determined in vitro against human erythrocyte or recombinant AChE and human plasmatic BChE. According to inhibitory ability values acquired, a structure - activity relationships were investigated in every series. A few compounds with significant affinity towards...
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Study of pyridine derivatives as potential antimycobacterial active drugs.
Nawrot, Daria Elżbieta ; Doležal, Martin (advisor) ; Musílek, Kamil (referee) ; Musiol, Robert (referee)
Univerzita Karlova, Farmaceutická fakulta v Hradci Králové Katedra Katedra farmaceutické chemie a farmaceutické analýzy Kandidát: Daria Nawrot Školitel: Prof. PharmDr. Martin Doležal, Ph.D. Název disertační práce: Studium derivátů pyridinu jako potenciálních antimykobakteriálních léčiv. Mimo období kdy tvořil COVID-19 největší hrozbu pro účinnost zdravotnických systémů na celosvětovém měřítku, zůstává tuberkuloza nejdůležitější příčinou úmrtí na infekční chorobu. Tato skutečnost, spolu se stoupající antibakteriální rezistencí, tvoří zásadní výzvu pro výzkum nových léčiv. Teoretická část tohoto komentáře krátce zvýrazňuje problematiku tuberkulozy a konkrétněji antimikrobiální rezistence. V experimentální části je vedena diskuze o návrhu, syntéze a biologickém hodnocení nových sloučenin zkoumaných během doktorského studia. Navržené sloučeniny byly připraveny a testovány na in vitro aktivitu proti vybraným mykobakteriálním kmenům (M. Avium, M. aurum, M. kansasii, M. smegmatis spolu s kmeny hlavního zájmu - Mtb H37Ra a H37Rv), osmi fungálním kmenům (Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis, Aspergillus fumigatus, Aspergillus flavus, Absidia corymbifera, a Trichophyton interdigitale) a osmi bakteriálním kmenům (Staphylococcus aureus, Escherichia coli, Pseudomonas...
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Synthesis of purine derivatives with potential antimycobacterial activity
Finger, Vladimír ; Roh, Jaroslav (advisor) ; Doležal, Martin (referee) ; Brulíková, Lucie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Doctoral Degree Program Bioorganic Chemistry Candidate: Ing. Vladimír Finger Supervisor: Assoc. Prof. PharmDr. Jaroslav Roh, Ph.D. Title of Doctoral Thesis: Synthesis of purine derivatives with potential antimycobacterial activity The theoretical part of this dissertation briefly summarizes basic data on tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis (Mtb.). The epidemiological data published in the annual report of the World Health Organization (WHO) and the structure of drugs used in current TB therapy are presented. The theoretical section also gives a brief overview of the treatment of TB and mentions four compounds that are currently in phase II clinical trials. The mechanism of action of these compounds is inhibition of the enzyme decaprenylphosphoryl-β-D-ribose-2'-epimerase, specifically the DprE1 subunit. This enzyme plays an important role in the synthesis of mycobacterial call wall. The next part of the dissertation summarizes the results of research on potential purine and pyrrolo[3,2- d]pyrimidine antituberculosis agents derived from purine-6-one 10. Compound 10 was identified as derivative with moderate anti-TB activity (MIC99(Mtb) = 4 μM) in a high-...
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Production of ethanol as an automotive fuel from renewable materials
Doležal, Martin ; Kropáč, Jiří (referee) ; Dlabaja, Tomáš (advisor)
The thesis deals with ethanol production using renewable energy ressources. It describes various manufacturing processes and the usage of respective input materials. It researches utilization of ethanol as engine fuel both as a mixture with conventional fuels and also as the principal component. Consequentionally, it proposes a design of combustion engines suitable for this fuel. Evaluation of advantages and disadvantages of substituting petrol products with bioethanol is provided. The thesis also includes energy and economic evaluation.
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Sewage disposal plant
Doležal, Martin ; Kraut, Jan (referee) ; Šulák, Pavel (advisor)
This thesis deals with the design and static assessment of a concrete part of a sewage treatment plant. Specifically, the calculation and assessment of the base plate, external walls, internal walls and ceiling slabs, elaboration of shape and reinforcement drawings of selected structural element. The concrete part of the Sewage disposal plant is all below ground level. Static system and the calculation of internal forces was carried out in Scia Engineer 2011 - student version.
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Commented translation of a text on science and technology
Doležal, Martin ; Smutný, Milan (referee) ; Krhutová, Milena (advisor)
Tato bakalářská práce se zabývá používáním technického jazyka v češtině i angličtině, v čem si jsou tyto jazyky podobné a v čem se naopak liší. Pro studování jazyků v elektrotechnice byl vybrán technicky zaměřený text k přeložení a poté byl přeložen do angličtiny. Po překladu byla provedena analýza jazyka, které se zaměřovala jak na lingvistické, tak extralingvistické vlastnosti, které jsou často specifické pro odborné texty. Tyto vlastnosti pokrývají širokou škálu lingvistických oborů, jako jsou například lexikologie, morfologie, stylistika, syntax, ale i extralingvistické záležitosti, jako třeba pragmatika. Analýza originálního a přeloženého textu odhalila spoustu rozdílů, jak malých, tak i velkých, které jsou výsledkem pokusu o přenos informace v jazyce, který je poměrně rozdílný oproti originálnímu jazyku.
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Universal Cabling Design for the Company GNT s.r.o
Doležal, Martin ; Koleňák, Jiří (referee) ; Ondrák, Viktor (advisor)
The thesis is to analyse and design universal cabling in a multi-functional house that will be subject to a thorough reconstruction. The house shall serve for business purposes of the company GNT, s.r.o.. The cabling design is based on investor´s requirements and the construction plan analysis of the house. There had been no computer network in the house. The thesis shall encompass a complete documentation of the project, and its estimated budget.
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The road bridge
Doležal, Martin ; Barnat, Jan (referee) ; Puchner, Josef (advisor)
This master' thesis deal with the desiggning of steel bearing structure of road bridge with span of 48,5m with lower bridge deck, which cross local road over the river Thaya in the town Znojmo. Three variants have been designed of arched bridge. The most economical variant was prepared in detail and wascarried out static assessment of individual elements and selected details. In detail solved variant is the bridge with free staing arches and lower bredge deck with composite crosspiece. The span of bridge is 48,5m, width of bridge is 11,5meters, free width of main trafic area 6,5m. Camber of bridge 8,0m
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