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Molecular genetic analysis of rare ocular disorders in Roma population from the Czech Republic
Rysková, Natálie ; Lišková, Petra (advisor) ; Klímová, Aneta (referee)
The Roma are the largest and most widespread transnational ethnic community. The Czech Republic estimates their 2% representation in its population. Due to the high level of endogamy, the spectrum and frequency of hereditary diseases in the Roma population differ from the majority population. Hereditary eye diseases are one of the most common causes of blindness in younger adults and thus represent a real socio-economic burden. The aim of the thesis was to perform molecular genetic analysis in individuals of Roma origin suffering from hereditary diseases affecting vision, including dual impairments and syndromes, and to determinate the frequency of the detected pathogenic variants in this population. Molecular genetic analysis of 17 families was performed using direct and whole exome sequencing. Within the framework of an international collaboration, the degree of their mutual kinship was calculated using the PLINK program. The frequency of selected variants was determined in a control dataset comprising 156 Roma exomes and genomes. The spectrum of analyzed diseases included various retinal dystrophies, primary congenital glaucoma, Usher syndrome, neuronal ceroid lipofuscinosis, Noonan syndrome, nanophthalmos and congenital cataract, facial dysmorphism and neuropathy. The results of the thesis...
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Consent: a New Literary Genre?
Klímová, Aneta ; Voldřichová - Beránková, Eva (advisor) ; Mengozzi, Chiara (referee)
The purpose of this bachelor thesis is to analyse the literary genre of Consent in order to determine whether it represents an emerging genre. Vanessa Springora's Consent is an autobiographical book that is part of the French version of the #MeToo movement, #balancetonporc. After three decades of silence, the author denounces the hold that writer Gabriel Matzneff had on her, both in her personal life and in his books. An autobiographical book, Consent does not fit into any of the traditional literary genres. In order to determine its literary genre, this thesis analyses Consent from the point of view of different autobiographical genres. It draws from the contemporary trends analysed in Dominique Viart and Bruno Vercier's methodological book La littérature française au present : Héritage, modernité, mutations.
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The Mechanism of Pathogenesis of Experimental Autoimmune Uveitis and Possilbilities of Their Regulation
Klímová, Aneta ; Heissigerová, Jarmila (advisor) ; Pitrová, Šárka (referee) ; Holáň, Vladimír (referee)
Introduction:Uveitis in an ocular inflammation affecting mostly people of working age. Uveitis is responsible for severe visual impairment despite of expanding new therapeutics. The animal models of uveitis were established, because the wide clinical variability of uveitis limits the studies in human medicine. The goal our project was to establish a reproducible model of experimental autoimmune uveitis in Czech Republic, and further on this model to observe the frequency of CD3+ and F4/80+ cells in retina, to assess the influence of microbial environment on intensity of intraocular inflammation and to test the therapeutical possibilities. Material and methods: The C57BL/6J mice were immunized by retinal antigen (IRBP 1-20, interphotoreceptor retinoid binding protein), enhanced by complete Freund's adjuvant and pertussis toxin and mild posterior autoimmune uveitis was induced. The mice were bred in conventional and germ-free (gnotobiotic) conditions. The uveitis intensity was evaluated in vivo biomicroscopically and post mortem histologically on hematoxylin eosin stained sections according to the standard protocol. The histological eye specimen were analyzed also by imunohistochemisty and by flow cytometry. Each experiment was performed for 35 days. The conventional mice with uveitis were treated...
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The Mechanism of Pathogenesis of Experimental Autoimmune Uveitis and Possilbilities of Their Regulation
Klímová, Aneta ; Heissigerová, Jarmila (advisor) ; Pitrová, Šárka (referee) ; Holáň, Vladimír (referee)
Introduction:Uveitis in an ocular inflammation affecting mostly people of working age. Uveitis is responsible for severe visual impairment despite of expanding new therapeutics. The animal models of uveitis were established, because the wide clinical variability of uveitis limits the studies in human medicine. The goal our project was to establish a reproducible model of experimental autoimmune uveitis in Czech Republic, and further on this model to observe the frequency of CD3+ and F4/80+ cells in retina, to assess the influence of microbial environment on intensity of intraocular inflammation and to test the therapeutical possibilities. Material and methods: The C57BL/6J mice were immunized by retinal antigen (IRBP 1-20, interphotoreceptor retinoid binding protein), enhanced by complete Freund's adjuvant and pertussis toxin and mild posterior autoimmune uveitis was induced. The mice were bred in conventional and germ-free (gnotobiotic) conditions. The uveitis intensity was evaluated in vivo biomicroscopically and post mortem histologically on hematoxylin eosin stained sections according to the standard protocol. The histological eye specimen were analyzed also by imunohistochemisty and by flow cytometry. Each experiment was performed for 35 days. The conventional mice with uveitis were treated...
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Statistical analysis of financial indicators ČSOB insurance, Inc. in the years 1993 – 2015
Klímová, Aneta ; Hošková, Pavla (advisor) ; Petr, Petr (referee)
This thesis focuses on the statistical analysis of the financial indicators the ČSOB insurance company inc. in the years 1993 to 2015. First is the issue of insurance from a global point of view, where in the context of financial markets ranks, what kinds of insurance there are etc. Furthermore, it is established by specific information from the analysis of ČSOB insurance company for historical and even current. In the next section also examines the issue of financial analysis, both in general concept and specifically tailored to the field of insurance. In the analytical part of the thesis is carried out first, the financial analysis of statements of insurance companies on financial analysis of standard and special financial indicators for insurance companies. Follow the elemental characteristics of time series, indicators, profit, number of employees, the premiums, the share of the insurance market and insurance indemnities. In the next section is discussed the insurance market in terms of competition and comparison the development of the situation CSOB pojistovna with the leader of the insurance Česká pojišťovna further by Kooperativa and Generali insurance company in the areas of profit, the prescribed profit and the number of contracts. The specified income and the number of contracts in this case have separately divided into life and non-life insurance. At the conclusion of the analytical part of the work are made a prediction for 2016 and 2017.
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Analysis of the social responsibility activities in the selected organization
Klímová, Aneta ; Plášková, Alena (advisor) ; Hykš, Ondřej (referee)
This Bachelor Thesis analyses the CSR (Corporate Social Responsibility) at IBM. The work is divided into two parts, the theoretical and the practical. The theoretical part deals with the basic concepts related to CSR. The practical part is focused on IBM and its external evaluation of the CSR in accordance with the Czech KORP method. The aim of the work is to evaluate IBM's corporate social responsibility and to propose options for improvement. The data needed for evaluation was assumed from GRI Report, Corporate Responsibility Report and websites.
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