Vývoj liquisolid systémů s cíleným přívodem léčiva do kolonu

Ogadah, Chiazor Ugo

Charles University, Faculty of Pharmacy in Hradec Králové Training workplace: Department of Pharmaceutical Technology Doctoral Degree program: Pharmaceutical Technology Candidate: Mgr. Chiazor Ugo Ogadah Supervisor: Assoc. Prof. PharmDr. Barbora Vraníková, Ph.D. Advisor: Assoc. Prof. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Doctoral Thesis: Development of liquisolid systems for colon targeting Colon-targeted drug delivery holds significant promise for the local treatment of colonic ailments or the systemic delivery of drugs. Nevertheless, the success is challenged by the physiological barriers within the gastrointestinal tract. Improving the solubility of the drug prior to targeting will circumvent the rate-limiting step of dissolution and enhance absorption and oral bioavailability. Additionally, retaining the formulation at the target site will optimize the dose and improve the therapeutic efficacy. Therefore, the aim of this thesis was to develop a drug delivery system that will potentially allow the targeting a poorly water-soluble drug, cyclosporine A (CyA), to the colon. In the first part of the experiments, the preformulation studies related to improving the solubility and dissolution rate of the CyA by the formulation of liquisolid systems (LSS) or interactive mixtures by co-milling...

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