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Název:
In silico Analysis of Rutin from Ruta chalepensis.L for NF-X1 Inhibition in Cervical Cancer: Insights from HPTLC studies
Autoři: Rajasekaran, Laxmipriya ; Pankaj, Vaishali ; Bhogal, Inderjeet ; Čejková, Darina
Typ dokumentu: Příspěvky z konference
Jazyk: eng
Nakladatel: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstrakt: Bioactive compounds play a pivotal role in the majority of pharmacological activities. Rutin, in particular, exhibits great potential in combination with antitumor drugs and various herbal formulations, enhancing permeability and regulating apoptosis induction. Earlier studies revealed the presence of alkaloids, flavonoids, phenols, quinines, and steroids among other compounds. Moreover, bioactive compounds were previously identified using GC-MS, with a total of 32 compounds identified within the plant sample Ruta chalepensis L, exhibiting several beneficial effects on leaf extract carried out through antioxidant properties. The leaves of Ruta chalepensis L were previously studied to evaluate the biological constituents and phytochemical screening. In this study, the biologically active compound was performed using high-performance thin-layer chromatography (HPTLC) plates silica gel 60 F 254, with rutin as a standard compound and methanol as a sample solvent. In cervical cancer, NF-X1 is transcriptional repressor which is highly expressed caused by HPV-associated drug compounds, was predicted to bind to rutin compound through in-silico modeling. In conclusion, it was found Rutin could be a potential modulator using molecular docking and simulation studies and has a potential therapeutic role in cervical cancer treatment.
Klíčová slova: HPTLC; in silico; NF-X1; Ruta chalepensis. L; Rutin
Zdrojový dokument: Proceedings I of the 30st Conference STUDENT EEICT 2024: General papers, ISBN 978-80-214-6231-1, ISSN 2788-1334
Instituce: Vysoké učení technické v Brně (web)
Informace o dostupnosti dokumentu: Plný text je dostupný v Digitální knihovně VUT.
Původní záznam: https://hdl.handle.net/11012/249236
Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-622521
Autoři: Rajasekaran, Laxmipriya ; Pankaj, Vaishali ; Bhogal, Inderjeet ; Čejková, Darina
Typ dokumentu: Příspěvky z konference
Jazyk: eng
Nakladatel: Vysoké učení technické v Brně, Fakulta elektrotechniky a komunikačních technologií
Abstrakt: Bioactive compounds play a pivotal role in the majority of pharmacological activities. Rutin, in particular, exhibits great potential in combination with antitumor drugs and various herbal formulations, enhancing permeability and regulating apoptosis induction. Earlier studies revealed the presence of alkaloids, flavonoids, phenols, quinines, and steroids among other compounds. Moreover, bioactive compounds were previously identified using GC-MS, with a total of 32 compounds identified within the plant sample Ruta chalepensis L, exhibiting several beneficial effects on leaf extract carried out through antioxidant properties. The leaves of Ruta chalepensis L were previously studied to evaluate the biological constituents and phytochemical screening. In this study, the biologically active compound was performed using high-performance thin-layer chromatography (HPTLC) plates silica gel 60 F 254, with rutin as a standard compound and methanol as a sample solvent. In cervical cancer, NF-X1 is transcriptional repressor which is highly expressed caused by HPV-associated drug compounds, was predicted to bind to rutin compound through in-silico modeling. In conclusion, it was found Rutin could be a potential modulator using molecular docking and simulation studies and has a potential therapeutic role in cervical cancer treatment.
Klíčová slova: HPTLC; in silico; NF-X1; Ruta chalepensis. L; Rutin
Zdrojový dokument: Proceedings I of the 30st Conference STUDENT EEICT 2024: General papers, ISBN 978-80-214-6231-1, ISSN 2788-1334
Instituce: Vysoké učení technické v Brně (web)
Informace o dostupnosti dokumentu: Plný text je dostupný v Digitální knihovně VUT.
Původní záznam: https://hdl.handle.net/11012/249236
Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-622521
Záznam vytvořen dne 2024-07-21, naposledy upraven 2024-07-21.