Original title: Synthesis of conformationally locked carbocyclic nucleosides with norbornane as pseudosugar moiety
Authors: Dejmek, Milan ; Hřebabecký, Hubert ; Šála, Michal ; Dračínský, Martin ; Nencka, Radim
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year: 2011
Language: eng
Abstract: We describe the chemical synthesis of three novel structural types of conformationally locked carbocyclic nucleosides with norbornane as sugar surrogate. The presented structures bear hydroxymethyl, nucleobase or both in the bridgehead positions of the norbornane pseudosugar and thus adopt three different conformations of the cyclopentane ring – North, South, and East.
Keywords: conformationally locked cyrbocyclic nucleosides; norbornane
Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP)
Funding provider: GA MŠk
Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0198268

Permalink: http://www.nusl.cz/ntk/nusl-55770


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers